Myocardial Fibrin Deposition in Experimental Viral Myocarditis That Progresses to Dilated Cardiomyopathy

• Published in: Circulation research Vol. 72; no. 4; pp. 914 - 920
• Main Authors: Schnitt, Stuart J, Stillman, Isaac E, Owings, Debra V, Kishimoto, Chiharu, Dvorak, Harold F, Abelmann, Walter H
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.04.1993; Lippincott
• Subjects: Animals; Biological and medical sciences; Cardiomyopathy, Dilated - etiology; Coxsackievirus Infections; Eosine Yellowish-(YS); Experimental viral diseases and models; Fibrin - metabolism; Fibrosis; Hematoxylin; Immunoenzyme Techniques; Infectious diseases; Male; Medical sciences; Mice; Mice, Inbred C3H; Myocarditis - complications; Myocarditis - microbiology; Myocarditis - pathology; Myocardium - metabolism; Myocardium - pathology; Staining and Labeling; Viral diseases; Coxsackievirus; Picornaviridae; Cardiomyopathy; Rodentia; Etiopathogenesis; Cardiovascular disease; Enterovirus; Myocardial disease; Infection; Virus; Myocarditis; Fibrin; Vertebrata; Experimental disease; Mammalia; Mouse; Heart disease; Animal; Viral disease; Fibrosis; Myocardium

Myocardial fibrosis is a characteristic late feature in cases of viral myocarditis that progress to dilated cardiomyopathy. However, the pathogenesis of the myocardial fibrosis in such cases is unknown. Prior studies have shown that in healing wounds and tumor stroma generation, interstitial fibrin...