Involvement of oxidative stress‐induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

• Published in: Journal of cellular physiology Vol. 236; no. 4; pp. 2725 - 2739
• Main Authors: Yang, Run‐Ze, Xu, Wen‐Ning, Zheng, Huo‐Liang, Zheng, Xin‐Feng, Li, Bo, Jiang, Lei‐Sheng, Jiang, Sheng‐Dan
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2021; John Wiley and Sons Inc
• Subjects: Animals; Annuli; Annulus Fibrosus - drug effects; Annulus Fibrosus - metabolism; Annulus Fibrosus - ultrastructure; Apoptosis; Autophagy; Butyl hydroperoxide; Carbolines - toxicity; Case-Control Studies; Cell death; Cells, Cultured; Deferoxamine; Deferoxamine - pharmacology; Degeneration; Degenerative disc disease; Disease Models, Animal; Ferritin; Ferroptosis; Ferroptosis - drug effects; Humans; intervertebral disc degeneration; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; Intervertebral Disc Degeneration - prevention & control; Intervertebral discs; Iron; Iron deficiency; Lipid Peroxidation; Lipids; Male; NCOA4; Nuclear Receptor Coactivators - genetics; Nuclear Receptor Coactivators - metabolism; Nuclei (cytology); Nucleus pulposus; Nucleus Pulposus - drug effects; Nucleus Pulposus - metabolism; Nucleus Pulposus - ultrastructure; Nutrient deficiency; Original; Original s; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; Peroxidation; Phagocytosis; Rats; Rats, Sprague-Dawley; Siderophores - pharmacology; Signal Transduction; Staining; tert-Butylhydroperoxide - toxicity; intervertebral disc degeneration; Ferroptosis; oxidative stress; NCOA4

Ferroptosis is a necrotic form of regulated cell death that was associated with lipid peroxidation and free iron‐mediated Fenton reactions. It has been reported that iron deficiency had been implicated in the pathogenesis of intervertebral disc degeneration (IVDD) by activating apoptosis. However, t...