Involvement of oxidative stress‐induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis - Yang, Run‐Ze; Xu, Wen‐Ning; Zheng, Huo‐Liang; Zheng, Xin‐Feng; Li, Bo; Jiang, Lei‐Sheng; Jiang, Sheng‐Dan (Journal of cellular physiology, 2021)
Keywords: Animals; Annuli; Annulus Fibrosus - drug effects; Annulus Fibrosus - metabolism; Annulus Fibrosus - ultrastructure; Apoptosis; Autophagy; Butyl hydroperoxide; Carbolines - toxicity; Case-Control Studies; Cell death; Cells, Cultured; Deferoxamine; Deferoxamine - pharmacology; Degeneration; Degenerative disc disease; Disease Models, Animal; Ferritin; Ferroptosis; Ferroptosis - drug effects; Humans; intervertebral disc degeneration; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; Intervertebral Disc Degeneration - prevention & control; Intervertebral discs; Iron; Iron deficiency; Lipid Peroxidation; Lipids; Male; NCOA4; Nuclear Receptor Coactivators - genetics; Nuclear Receptor Coactivators - metabolism; Nuclei (cytology); Nucleus pulposus; Nucleus Pulposus - drug effects; Nucleus Pulposus - metabolism; Nucleus Pulposus - ultrastructure; Nutrient deficiency; Original; Original s; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; Peroxidation; Phagocytosis; Rats; Rats, Sprague-Dawley; Siderophores - pharmacology; Signal Transduction; Staining; tert-Butylhydroperoxide - toxicity; intervertebral disc degeneration; Ferroptosis; oxidative stress; NCOA4