Failure of oesophageal acid control in candidates for Barrett's oesophagus reversal on a very high dose of proton pump inhibitor

• Published in: Alimentary pharmacology & therapeutics Vol. 14; no. 5; pp. 597 - 602
• Main Authors: FASS, R, SAMPLINER, R. E, MALAGON, I. B, HAYDEN, C. W, CAMARGO, L, WENDEL, C. S, GAREWAL, H. S
• Format: Journal Article
• Language: English
• Published: Oxford UK Blackwell Publishing Ltd 01.05.2000; Blackwell
• Subjects: Adult; Age Factors; Aged; Anti-Ulcer Agents - pharmacology; Barrett Esophagus - drug therapy; Barrett Esophagus - physiopathology; Biological and medical sciences; Digestive system; Drug Resistance; Esophagus - chemistry; Female; Gastric Acid; Humans; Hydrogen-Ion Concentration; Male; Medical sciences; Middle Aged; Omeprazole - pharmacology; Pharmacology. Drug treatments; Prospective Studies; Proton Pump Inhibitors; Human; Treatment efficiency; Esophageal disease; Antiulcer agent; Barrett esophagus; Biological activity; Proton pump inhibitor; Omeprazole; Chemotherapy; Treatment; Benzimidazole derivatives; Antisecretory agent; Interindividual comparison; pH; Digestive diseases; High dose; Age

Background: Normalization of oesophageal acid exposure using high dose proton pump inhibitors in patients who are candidates for ablation therapy has been suggested to be essential for successful Barrett's reversal. However, the success rate for achieving pH normalization has not been determine...