Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition

• Published in: Lasers in surgery and medicine Vol. 52; no. 3; pp. 259 - 275
• Main Authors: Ford, Jeremy B., Ganguly, Mohit, Poorman, Megan E., Grissom, William A., Jenkins, Michael W., Chiel, Hillel J., Jansen, E. Duco
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2020
• Subjects: Action potential; Action Potentials - radiation effects; Animals; Aplysia; Axons; block length; Computational neuroscience; Computer simulation; Equipment Design; Exposure; Fiber Optic Technology; Fibers; Heat; heat block; High temperature; Hot Temperature; infrared inhibition; infrared neural inhibition; Infrared Rays; Invertebrates; Irradiation; Laser beam heating; Lasers; Magnetic resonance; Magnetic Resonance Imaging; Maxima; Nerves; Neural Inhibition - radiation effects; neuromodulation; neurophotonics; Optical communication; Optical fibers; optical inhibition; optical modulation; Proof of Concept Study; Reduction; Standard error; Temperature; Temperature dependence; Temperature distribution; Temperature requirements; Thermal Conductivity; Thermocouples; Water baths; heat block; infrared inhibition; neuromodulation; optical modulation; infrared neural inhibition; block length; neurophotonics; optical inhibition

Background and Objectives The objective of this study is to assess the hypothesis that the length of axon heated, defined here as block length (BL), affects the temperature required for thermal inhibition of action potential propagation applied using laser heating. The presence of such a phenomenon...