Immunogenetics in stem cell donor registry work: The DKMS example (Part 2)

DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two‐part review article, we deal with these aspects of donor registry work by using the example of DKMS. In th...

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Published inInternational journal of immunogenetics Vol. 47; no. 2; pp. 139 - 148
Main Authors Schmidt, Alexander H., Sauter, Jürgen, Baier, Daniel M., Daiss, Jessica, Keller, Andreas, Klussmeier, Anja, Mengling, Thilo, Rall, Gabi, Riethmüller, Tobias, Schöfl, Gerhard, Solloch, Ute V., Torosian, Tigran, Means, David, Kelly, Helen, Jagannathan, Latha, Paul, Patrick, Giani, Anette S., Hildebrand, Sabine, Schumacher, Stephan, Markert, Jan, Füssel, Monika, Hofmann, Jan A., Schäfer, Thomas, Pingel, Julia, Lange, Vinzenz, Schetelig, Johannes
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.04.2020
John Wiley and Sons Inc
Subjects
Alleles
Blood Grouping and Crossmatching
CMV
DKMS
donor registry
Genotype
Hematopoietic Stem Cell Transplantation
Histocompatibility antigen HLA
Histocompatibility Testing
HLA
HLA Antigens - genetics
Immunogenetics
KIR
MICA/MICB
Pharmacogenetics
Population genetics
Registries
Review
Stem cells
Stem Cells - immunology
Tissue Donors
Tissue typing
unrelated hematopoietic stem cell transplantation
MICA/MICB
KIR
donor registry
HLA
unrelated hematopoietic stem cell transplantation
CMV
DKMS
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Abstract DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two‐part review article, we deal with these aspects of donor registry work by using the example of DKMS. In the second part of the review, we focus on donor typing of non‐HLA genes, the impact of donor age, gender and CMV serostatus on donation probabilities, the identification of novel HLA, KIR and MIC alleles by high‐throughput donor typing, the activities of the Collaborative Biobank and pharmacogenetics in the donor registry context.
AbstractList DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two-part review article, we deal with these aspects of donor registry work by using the example of DKMS. In the second part of the review, we focus on donor typing of non-HLA genes, the impact of donor age, gender and CMV serostatus on donation probabilities, the identification of novel HLA, KIR and MIC alleles by high-throughput donor typing, the activities of the Collaborative Biobank and pharmacogenetics in the donor registry context.
Abstract DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two‐part review article, we deal with these aspects of donor registry work by using the example of DKMS. In the second part of the review, we focus on donor typing of non‐HLA genes, the impact of donor age, gender and CMV serostatus on donation probabilities, the identification of novel HLA, KIR and MIC alleles by high‐throughput donor typing, the activities of the Collaborative Biobank and pharmacogenetics in the donor registry context.
Author Mengling, Thilo
Lange, Vinzenz
Solloch, Ute V.
Jagannathan, Latha
Torosian, Tigran
Riethmüller, Tobias
Schetelig, Johannes
Rall, Gabi
Baier, Daniel M.
Klussmeier, Anja
Daiss, Jessica
Schäfer, Thomas
Sauter, Jürgen
Means, David
Keller, Andreas
Markert, Jan
Hofmann, Jan A.
Giani, Anette S.
Schöfl, Gerhard
Schumacher, Stephan
Kelly, Helen
Hildebrand, Sabine
Füssel, Monika
Schmidt, Alexander H.
Pingel, Julia
Paul, Patrick
AuthorAffiliation 4 Fundacja DKMS Warsaw Poland
9 Fundación de Beneficencia Pública DKMS Santiago Chile
6 DKMS UK London UK
8 Bangalore Medical Services Trust Bangalore India
5 DKMS US New York NY USA
2 DKMS Life Science Lab Dresden Germany
3 Clinical Trials Unit DKMS Dresden Germany
1 DKMS Tübingen Germany
10 Medizinische Klinik I University Hospital Carl Gustav Carus Dresden Germany
7 DKMS‐BMST Foundation India Bangalore India
AuthorAffiliation_xml – name: 2 DKMS Life Science Lab Dresden Germany
– name: 8 Bangalore Medical Services Trust Bangalore India
– name: 1 DKMS Tübingen Germany
– name: 9 Fundación de Beneficencia Pública DKMS Santiago Chile
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– name: 10 Medizinische Klinik I University Hospital Carl Gustav Carus Dresden Germany
– name: 3 Clinical Trials Unit DKMS Dresden Germany
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Author_xml – sequence: 1
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Issue 2
Keywords MICA/MICB
KIR
donor registry
HLA
unrelated hematopoietic stem cell transplantation
CMV
DKMS
Language English
License Attribution-NonCommercial
2020 The Authors. International Journal of Immunogenetics . Published by John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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Snippet DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics...
Abstract DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from...
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SubjectTerms Alleles
Blood Grouping and Crossmatching
CMV
DKMS
donor registry
Genotype
Hematopoietic Stem Cell Transplantation
Histocompatibility antigen HLA
Histocompatibility Testing
HLA
HLA Antigens - genetics
Immunogenetics
KIR
MICA/MICB
Pharmacogenetics
Population genetics
Registries
Review
Stem cells
Stem Cells - immunology
Tissue Donors
Tissue typing
unrelated hematopoietic stem cell transplantation
Title Immunogenetics in stem cell donor registry work: The DKMS example (Part 2)
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fiji.12479
https://www.ncbi.nlm.nih.gov/pubmed/32034894
https://www.proquest.com/docview/2370268608
https://search.proquest.com/docview/2352657480
https://pubmed.ncbi.nlm.nih.gov/PMC7079094
Volume 47
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