Antibodies against biotin‐labeled red blood cells can shorten posttransfusion survival

• Published in: Transfusion (Philadelphia, Pa.) Vol. 62; no. 4; pp. 770 - 782
• Main Authors: Mock, Donald M., Stowell, Sean R., Franco, Robert S., Kyosseva, Svetlana V., Nalbant, Demet, Schmidt, Robert L., Cress, Gretchen A., Strauss, Ronald G., Cancelas, José A., Goetz, Melissa, North, Anne K., Widness, John A.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2022; Wiley Subscription Services, Inc
• Subjects: Adult; Albumins; Antibodies; Antibodies - metabolism; Antibody response; BioRBC antibodies; Biotin; Biotin - chemistry; biotin‐labeled RBC; Cell Survival; Chromium radioisotopes; Density; Epitopes; Erythrocyte Count; Erythrocytes; Erythrocytes - metabolism; Exposure; Humans; Immunization; Immunoglobulin G; RBC posttransfusion kinetics; Survival; Transfusion; biotin-labeled RBC; BioRBC antibodies; RBC posttransfusion kinetics; biotin

Background In hematologic and transfusion medicine research, measurement of red blood cell (RBC) in vivo kinetics must be safe and accurate. Recent reports indicate use of biotin‐labeled RBC (BioRBC) to determine red cell survival (RCS) offers substantial advantages over 51Cr and other labeling meth...