Gene expression in chronic granulomatous disease and interferon‐γ receptor‐deficient cells treated in vitro with interferon‐γ

• Published in: Journal of cellular biochemistry Vol. 120; no. 3; pp. 4321 - 4332
• Main Authors: Frazão, Josias B., Colombo, Martino, Simillion, Cedric, Bilican, Adem, Keller, Irene, Wüthrich, Daniel, Zhu, Zhiqing, Okoniewski, Michal J., Bruggmann, Rémy, Condino‐Neto, Antonio, Newburger, Peter E.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2019
• Subjects: Adaptive immunity; Antigen presentation; B-Lymphocytes - metabolism; B-Lymphocytes - virology; Cell adhesion; Cell adhesion & migration; Cell Line; Chronic granulomatous disease; Disease control; Epstein-Barr virus; Exons; Exons - genetics; Gene expression; Gene Expression - drug effects; Gene regulation; Genes; Granulomatous Disease, Chronic - blood; Granulomatous Disease, Chronic - genetics; Granulomatous Disease, Chronic - pathology; Herpesvirus 4, Human; Humans; Immune response; Immunity; Interferon; Interferon gamma Receptor; Interferon-gamma - pharmacology; interferon‐γ; interferon‐γ receptor deficiency; Interleukins; Lymphocytes; Lymphocytes B; Nitric oxide; Nitric-oxide synthase; Patients; phagocyte; Proteasomes; Protein biosynthesis; Protein synthesis; Proteins; Receptors, Interferon - deficiency; Ribonucleic acid; RNA; RNA processing; RNA Splicing - genetics; RNA, Messenger - genetics; RNA-Seq; Signal Transduction - drug effects; Splicing; transcriptome; Transfer RNA; Tryptophan-tRNA Ligase - genetics; Viruses; γ-Interferon; interferon-γ; interferon-γ receptor deficiency; phagocyte; chronic granulomatous disease; transcriptome

Interferon‐γ (IFN‐γ) plays an important role in innate and adaptive immunity against intracellular infections and is used clinically for the prevention and control of infections in chronic granulomatous disease (CGD) and inborn defects in the IFN‐γ/interleukin (IL)‐12 axis. Using transcriptome profi...