Novel synthetic chalcone‐coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection

• Published in: CNS neuroscience & therapeutics Vol. 24; no. 12; pp. 1286 - 1298
• Main Authors: Lee, Shin‐Ying, Chiu, Ya‐Jen, Yang, Shu‐Mei, Chen, Chiung‐Mei, Huang, Chin‐Chang, Lee‐Chen, Guey‐Jen, Lin, Wenwei, Chang, Kuo‐Hsuan
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2018; John Wiley and Sons Inc
• Subjects: Acetylcholinesterase; Acetylcholinesterase - metabolism; Alzheimer's disease; Amyloid; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Antioxidants; Antioxidants - pharmacology; antioxidation; Axonogenesis; Aβ aggregation reduction; Brain-derived neurotrophic factor; Cell culture; Cell Line, Tumor; Chalcone - chemistry; Chalcone - pharmacology; chalcone‐coumarin hybrid; Coumarin; Coumarins - chemistry; Coumarins - pharmacology; Cyclic AMP response element-binding protein; Dose-Response Relationship, Drug; Free radicals; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Humans; Inhibitory Concentration 50; Licochalcone A; Neuroblastoma - pathology; Neurodegenerative diseases; Neuronal Outgrowth - drug effects; Neuroprotection; Original; Oxidative stress; Protein Aggregates - drug effects; Reactive oxygen species; Reactive Oxygen Species - metabolism; RNA Interference - drug effects; RNA, Messenger - metabolism; Senile plaques; therapeutics; Toxicity; Transfection; chalcone‐coumarin hybrid; therapeutics; antioxidation; Alzheimer’s disease; neuroprotection; Aβ aggregation reduction

Background Aggregation of misfolded amyloid β (Aβ) in senile plaques causes oxidative stress and neuronal death in Alzheimer's disease (AD). Compounds possessing antiaggregation and antioxidant properties are promising candidate compounds for AD treatment. Methods We examined the potential of s...