Novel synthetic chalcone‐coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection - Lee, Shin‐Ying; Chiu, Ya‐Jen; Yang, Shu‐Mei; Chen, Chiung‐Mei; Huang, Chin‐Chang; Lee‐Chen, Guey‐Jen; Lin, Wenwei; Chang, Kuo‐Hsuan (CNS neuroscience & therapeutics, 2018)
Keywords: Acetylcholinesterase; Acetylcholinesterase - metabolism; Alzheimer's disease; Amyloid; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Antioxidants; Antioxidants - pharmacology; antioxidation; Axonogenesis; Aβ aggregation reduction; Brain-derived neurotrophic factor; Cell culture; Cell Line, Tumor; Chalcone - chemistry; Chalcone - pharmacology; chalcone‐coumarin hybrid; Coumarin; Coumarins - chemistry; Coumarins - pharmacology; Cyclic AMP response element-binding protein; Dose-Response Relationship, Drug; Free radicals; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Humans; Inhibitory Concentration 50; Licochalcone A; Neuroblastoma - pathology; Neurodegenerative diseases; Neuronal Outgrowth - drug effects; Neuroprotection; Original; Oxidative stress; Protein Aggregates - drug effects; Reactive oxygen species; Reactive Oxygen Species - metabolism; RNA Interference - drug effects; RNA, Messenger - metabolism; Senile plaques; therapeutics; Toxicity; Transfection; chalcone‐coumarin hybrid; therapeutics; antioxidation; Alzheimer’s disease; neuroprotection; Aβ aggregation reduction