Design of the Magnetic Resonance Imaging Evaluation of Mineralocorticoid Receptor Antagonism in Diabetic Atherosclerosis (MAGMA) Trial - Rajagopalan, Sanjay; Alaiti, M. Amer; Broadwater, Kylene; Goud, Aditya; Gaztanaga, Juan; Connelly, Kim; Fares, Anas; Shirazian, Shayan; Kreatsoulas, Catherine; Farkouh, Michael; Dobre, Mirela; Fink, Jeffrey C.; et al. (Clinical cardiology (Mahwah, N.J.), 2017)
Keywords: Aorta, Thoracic - diagnostic imaging; Aorta, Thoracic - drug effects; Aorta, Thoracic - pathology; Aortic Diseases - diagnostic imaging; Aortic Diseases - etiology; Aortic Diseases - pathology; Aortic Diseases - prevention & control; Atherosclerosis; Atherosclerosis - diagnostic imaging; Atherosclerosis - etiology; Atherosclerosis - pathology; Atherosclerosis - prevention & control; Blood pressure; Clinical Protocols; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - drug therapy; Diabetic Angiopathies - diagnostic imaging; Diabetic Angiopathies - etiology; Diabetic Angiopathies - pathology; Diabetic Angiopathies - prevention & control; Double-Blind Method; Female; Humans; Inflammation; Kidney diseases; Macrophage; Magnetic Resonance Imaging; Male; Middle Aged; Mineralocorticoid Receptor; Mineralocorticoid Receptor Antagonists - adverse effects; Mineralocorticoid Receptor Antagonists - therapeutic use; miRNA; Monocyte; Plaque, Atherosclerotic; Predictive Value of Tests; Proof of Concept Study; Prospective Studies; Research Design; Signal Transduction - drug effects; Spironolactone - adverse effects; Spironolactone - therapeutic use; Treatment Outcome; Trial Designs; United States; Ventricular Function, Left - drug effects; Ventricular Remodeling - drug effects; Magnetic Resonance Imaging; Monocyte; Atherosclerosis; miRNA; Inflammation; Mineralocorticoid Receptor; Macrophage