Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance

• Published in: Diabetes/metabolism research and reviews Vol. 35; no. 2; pp. e3087 - n/a
• Main Authors: Kochumon, Shihab, Al‐Rashed, Fatema, Abu‐Farha, Mohamed, Devarajan, Sriraman, Tuomilehto, Jaakko, Ahmad, Rasheed
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.02.2019; John Wiley and Sons Inc
• Subjects: Adiponectin; Adipose tissue; Adipose Tissue - metabolism; Adult; Biomarkers - analysis; Blood glucose; Body mass index; Body weight; Case-Control Studies; CCL19; CCL19 protein; CCR2 protein; CCR5 protein; Chemokine CCL19 - genetics; Chemokine CCL19 - metabolism; Chemokines; Cholesterol; Diabetes mellitus; Enzyme-linked immunosorbent assay; Female; Follow-Up Studies; Gene expression; Glucose; Hemoglobin; High density lipoprotein; Homeostasis; Humans; Inflammation; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Insulin; Insulin Resistance; Male; metabolic inflammation; Metabolism; Monocyte chemoattractant protein 1; Multiple regression analysis; Obesity; Obesity - complications; Overweight; Overweight - complications; Prognosis; Thinness; Triglycerides; adipose tissue; CCL19; insulin resistance; metabolic inflammation; obesity

Background Chemokines produced by adipose tissue (AT) are involved in the development of chronic low‐grade inflammation in obese humans and rodents. AT CCL19 expression in obesity and its association with metabolic inflammation and insulin resistance are poorly understood. This study aimed to invest...