Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress - Tian, Yuan‐Qing; Li, Jia‐Hui; Li, Yong‐Chang; Xu, Yu‐Cheng; Zhang, Ping‐An; Wang, Qian; Li, Rui; Xu, Guang‐Yin (CNS neuroscience & therapeutics, 2022)
Keywords: Abdomen; Age; Animals; anterior cingulate cortex; Cortex (cingulate); Disease Models, Animal; Distension; Down-Regulation; Drug withdrawal; Experiments; Female; G-Protein-Coupled Receptor Kinases; GRK6; Gyrus Cinguli; Humans; Hypersensitivity; Immunohistochemistry; Immunoprecipitation; Inflammation; Information processing; Irritable Bowel Syndrome; Kinases; Laboratory animals; Membrane proteins; Microinjection; mRNA; Nervous system; Original; P2Y6; Pain; Phosphorylation; Pregnancy; Prenatal experience; prenatal maternal stress; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; RNA, Messenger; Rodents; Software; visceral pain; Visceral Pain - pathology; Western blotting; visceral pain; P2Y6; anterior cingulate cortex; GRK6; prenatal maternal stress