MicroRNA‐204‐5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans

• Published in: Journal of cellular physiology Vol. 235; no. 12; pp. 9851 - 9863
• Main Authors: Houzelle, Alexandre, Dahlmans, Dennis, Nascimento, Emmani B. M., Schaart, Gert, Jörgensen, Johanna A., Moonen‐Kornips, Esther, Kersten, Sander, Wang, Xu, Hoeks, Joris
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2020; John Wiley and Sons Inc
• Subjects: Animals; Autophagy; Autophagy - genetics; Biomarkers; Biopsy; Biosynthesis; C2C12; Chromosome 5; Citrate synthase; Confocal microscopy; Copy number; Deoxyribonucleic acid; DNA; DNA microarrays; Gene expression; Humans; Metabolism; Mice; microRNA; MicroRNAs; MicroRNAs - genetics; miRNA; mitochondria; Mitochondria - genetics; Mitochondria, Muscle - genetics; Mitochondria, Muscle - metabolism; Mitochondrial DNA; mitophagy; Mitophagy - genetics; Morphology; Muscle Fibers, Skeletal - metabolism; Muscle, Skeletal - metabolism; Muscles; Musculoskeletal system; Myocytes; Myotubes; Organelle Biogenesis; Original; Original s; Oxidation-Reduction; Oxidative Stress - genetics; Phagocytosis; Polymerase chain reaction; Protein B; Proteins; Ribonucleic acid; RNA; Skeletal muscle; Transcription; microRNA; C2C12; mitophagy; skeletal muscle; mitochondria

Using an unbiased high‐throughput microRNA (miRNA)‐silencing screen combined with functional readouts for mitochondrial oxidative capacity in C2C12 myocytes, we previously identified 19 miRNAs as putative regulators of skeletal muscle mitochondrial metabolism. In the current study, we highlight miRN...