Hydrogen bond design principles

• Published in: Wiley interdisciplinary reviews. Computational molecular science Vol. 10; no. 6
• Main Authors: Karas, Lucas J, Wu, Chia-Hua, Das, Ranjita, Wu, Judy I-Chia
• Format: Journal Article
• Language: English
• Published: United States 01.11.2020
• Subjects: hydrogen bonding; resonance-assisted hydrogen bonding; secondary electrostatic interactions; aromaticity

Hydrogen bonding principles are at the core of supramolecular design. This overview features a discussion relating molecular structure to hydrogen bond strengths, highlighting the following electronic effects on hydrogen bonding: electronegativity, steric effects, electrostatic effects, π-conjugatio...