Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury

• Published in: Journal of leukocyte biology Vol. 103; no. 5; pp. 919 - 932
• Main Authors: Abdulnour, Raja‐Elie E., Howrylak, Judie A., Tavares, Alexander H., Douda, David N., Henkels, Karen M., Miller, Taylor E., Fredenburgh, Laura E., Baron, Rebecca M., Gomez‐Cambronero, Julian, Levy, Bruce D.
• Format: Journal Article
• Language: English
• Published: United States 01.05.2018
• Subjects: acute lung injury; Acute Lung Injury - immunology; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; acute respiratory distress syndrome; Animals; Case-Control Studies; Cells, Cultured; Female; Humans; Leukocytes - immunology; Leukocytes - metabolism; Leukocytes - pathology; Lung - immunology; Lung - metabolism; Lung - pathology; Macrophages - immunology; Macrophages - metabolism; Macrophages - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; microarray; Neutrophils - immunology; Neutrophils - metabolism; Neutrophils - pathology; Phagocytosis; Phospholipase D; Phospholipase D - physiology; Protein Isoforms; Respiratory Distress Syndrome, Adult - metabolism; Respiratory Distress Syndrome, Adult - pathology; acute respiratory distress syndrome; microarray; acute lung injury; Phospholipase D

Phospholipase D (PLD) plays important roles in cellular responses to tissue injury that are critical to acute inflammatory diseases, such as the acute respiratory distress syndrome (ARDS). We investigated the expression of PLD isoforms and related phospholipid phosphatases in patients with ARDS, and...