Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model

• Published in: Cancer Science Vol. 115; no. 8; pp. 2839 - 2845
• Main Authors: Okumura, Kazuhiro, Morinaga, Takao, Saito, Megumi, Tokunaga, Yurika, Otoyama, Keisuke, Tanaka, Sora, Isogai, Eriko, Kawazu, Masahito, Togashi, Yosuke, Hasegawa, Yoshinori, Wakabayashi, Yuichi
• Format: Journal Article
• Language: English
• Published: England Wiley 01.08.2024; John Wiley & Sons, Inc
• Subjects: 9,10-Dimethyl-1,2-benzanthracene - toxicity; Allosteric properties; Animals; Antibodies; Carcinogenesis; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; CD8 antigen; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - metabolism; Cell differentiation; Cell Differentiation - drug effects; Cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Disease Models, Animal; DMBA/TPA; Female; Genes; Genetic analysis; Immune response; Keratin; Kinases; Metastases; Mice; Morphology; mouse; p21-Activated Kinases - antagonists & inhibitors; p21-Activated Kinases - genetics; p21-Activated Kinases - metabolism; PAK1 inhibitor; Phosphorylation; Sequence analysis; Skin cancer; Skin Neoplasms - drug therapy; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Squamous cell carcinoma; Syngeneic grafts; syngenic model; Tetradecanoylphorbol Acetate; Tumors; PAK1 inhibitor; mouse; DMBA/TPA; syngenic model; squamous cell carcinoma

By taking advantage of forward genetic analysis in mice, we have demonstrated that Pak1 plays a crucial role during DMBA/TPA skin carcinogenesis. Although Pak1 has been considered to promote cancer development, its overall function remains poorly understood. To clarify the functional significance of...