Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model - Okumura, Kazuhiro; Morinaga, Takao; Saito, Megumi; Tokunaga, Yurika; Otoyama, Keisuke; Tanaka, Sora; Isogai, Eriko; Kawazu, Masahito; Togashi, Yosuke; Hasegawa, Yoshinori; Wakabayashi, Yuichi (Cancer Science, 2024)
Keywords: 9,10-Dimethyl-1,2-benzanthracene - toxicity; Allosteric properties; Animals; Antibodies; Carcinogenesis; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; CD8 antigen; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - metabolism; Cell differentiation; Cell Differentiation - drug effects; Cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Disease Models, Animal; DMBA/TPA; Female; Genes; Genetic analysis; Immune response; Keratin; Kinases; Metastases; Mice; Morphology; mouse; p21-Activated Kinases - antagonists & inhibitors; p21-Activated Kinases - genetics; p21-Activated Kinases - metabolism; PAK1 inhibitor; Phosphorylation; Sequence analysis; Skin cancer; Skin Neoplasms - drug therapy; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Squamous cell carcinoma; Syngeneic grafts; syngenic model; Tetradecanoylphorbol Acetate; Tumors; PAK1 inhibitor; mouse; DMBA/TPA; syngenic model; squamous cell carcinoma