Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

• Published in: Annals of neurology Vol. 88; no. 3; pp. 513 - 525
• Main Authors: Arvanitakis, Zoe, Wang, Hoau‐Yan, Capuano, Ana W., Khan, Amber, Taïb, Bouchra, Anokye‐Danso, Frederick, Schneider, Julie A., Bennett, David A., Ahima, Rexford S., Arnold, Steven E.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2020; Wiley Subscription Services, Inc
• Subjects: Aged, 80 and over; AKT protein; AKT1 protein; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Autopsy; Brain; Brain - metabolism; Brain - pathology; Cognition; Cognition & reasoning; Cognition - physiology; Cognitive ability; Correlation analysis; Cortex (frontal); Death; Diabetes; Diabetes mellitus; Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Female; Frontal gyrus; Growth factors; Humans; Immunohistochemistry; Insulin; Insulin - metabolism; Kinases; Male; Mortality; Neurodegenerative diseases; Neuropathology; Older people; Pathology; Phosphorylation; Protein kinase; Regression analysis; Signal Transduction; Signaling; Standard error; Stimulation; Substrates; Tau protein; Threonine

Objective To examine associations of molecular markers of brain insulin signaling with Alzheimer disease (AD) and cognition among older persons with or without diabetes. Methods This clinical–pathologic study was derived from a community‐based cohort study, the Religious Orders Study. We studied 150...