Childhood Bone Mineral Content Is Associated With Methylation Status of the RXRA Promoter at Birth

ABSTRACT Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid‐X receptor‐alpha (RXRA) is an essential cofactor in the action of 1,25‐dihydroxyvitamin D (1,25[OH]2‐vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later...

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Published inJournal of bone and mineral research Vol. 29; no. 3; pp. 600 - 607
Main Authors Harvey, Nicholas C, Sheppard, Allan, Godfrey, Keith M, McLean, Cameron, Garratt, Emma, Ntani, Georgia, Davies, Lucy, Murray, Robert, Inskip, Hazel M, Gluckman, Peter D, Hanson, Mark A, Lillycrop, Karen A, Cooper, Cyrus
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.03.2014
Subjects
Adult
Bone Density
Child
Child, Preschool
CpG Islands
DNA Methylation
DXA
Electrophoretic Mobility Shift Assay
EPIGENETIC
Female
Humans
Male
METHYLATION
Promoter Regions, Genetic
Prospective Studies
Retinoid X Receptor alpha - genetics
RXRA
UMBILICAL CORD
VITAMIN D
Vitamin D - analogs & derivatives
Vitamin D - blood
METHYLATION
EPIGENETIC
RXRA
UMBILICAL CORD
DXA
VITAMIN D
Online AccessGet full text
ISSN0884-0431
1523-4681
1523-4681
DOI10.1002/jbmr.2056

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Abstract ABSTRACT Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid‐X receptor‐alpha (RXRA) is an essential cofactor in the action of 1,25‐dihydroxyvitamin D (1,25[OH]2‐vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual‐energy X‐ray absorptiometry, in a population‐based mother‐offspring cohort (Southampton Women's Survey). Relationships between maternal plasma 25‐hydroxyvitamin D (25[OH]‐vitamin D) concentrations and cord RXRA methylation were also investigated. In 230 children aged 4 years, a higher percent methylation at four of six RXRA CpG sites measured was correlated with lower offspring bone mineral content (BMC) corrected for body size (β = −2.1 to −3.4 g/SD, p = 0.002 to 0.047). In a second independent cohort (n = 64), similar negative associations at two of these CpG sites, but positive associations at the two remaining sites, were observed; however, none of the relationships in this replication cohort achieved statistical significance. The maternal free 25(OH)‐vitamin D index was negatively associated with methylation at one of these RXRA CpG sites (β = −3.3 SD/unit, p = 0.03). Thus, perinatal epigenetic marking at the RXRA promoter region in umbilical cord was inversely associated with offspring size–corrected BMC in childhood. The potential mechanistic and functional significance of this finding remains a subject for further investigation. © 2014 American Society for Bone and Mineral Research.
AbstractList Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the action of 1,25-dihydroxyvitamin D (1,25[OH]2-vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual-energy X-ray absorptiometry, in a population-based mother-offspring cohort (Southampton Women's Survey). Relationships between maternal plasma 25-hydroxyvitamin D (25[OH]-vitamin D) concentrations and cord RXRA methylation were also investigated. In 230 children aged 4 years, a higher percent methylation at four of six RXRA CpG sites measured was correlated with lower offspring bone mineral content (BMC) corrected for body size ([beta]=-2.1 to -3.4g/SD, p=0.002 to 0.047). In a second independent cohort (n=64), similar negative associations at two of these CpG sites, but positive associations at the two remaining sites, were observed; however, none of the relationships in this replication cohort achieved statistical significance. The maternal free 25(OH)-vitamin D index was negatively associated with methylation at one of these RXRA CpG sites ([beta]=-3.3 SD/unit, p=0.03). Thus, perinatal epigenetic marking at the RXRA promoter region in umbilical cord was inversely associated with offspring size-corrected BMC in childhood. The potential mechanistic and functional significance of this finding remains a subject for further investigation. © 2014 American Society for Bone and Mineral Research. [PUBLICATION ABSTRACT]
Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the action of 1,25-dihydroxyvitamin D (1,25[OH]2 -vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual-energy X-ray absorptiometry, in a population-based mother-offspring cohort (Southampton Women's Survey). Relationships between maternal plasma 25-hydroxyvitamin D (25[OH]-vitamin D) concentrations and cord RXRA methylation were also investigated. In 230 children aged 4 years, a higher percent methylation at four of six RXRA CpG sites measured was correlated with lower offspring bone mineral content (BMC) corrected for body size (β = -2.1 to -3.4 g/SD, p = 0.002 to 0.047). In a second independent cohort (n = 64), similar negative associations at two of these CpG sites, but positive associations at the two remaining sites, were observed; however, none of the relationships in this replication cohort achieved statistical significance. The maternal free 25(OH)-vitamin D index was negatively associated with methylation at one of these RXRA CpG sites (β = -3.3 SD/unit, p = 0.03). Thus, perinatal epigenetic marking at the RXRA promoter region in umbilical cord was inversely associated with offspring size-corrected BMC in childhood. The potential mechanistic and functional significance of this finding remains a subject for further investigation.
ABSTRACT Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid‐X receptor‐alpha (RXRA) is an essential cofactor in the action of 1,25‐dihydroxyvitamin D (1,25[OH]2‐vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual‐energy X‐ray absorptiometry, in a population‐based mother‐offspring cohort (Southampton Women's Survey). Relationships between maternal plasma 25‐hydroxyvitamin D (25[OH]‐vitamin D) concentrations and cord RXRA methylation were also investigated. In 230 children aged 4 years, a higher percent methylation at four of six RXRA CpG sites measured was correlated with lower offspring bone mineral content (BMC) corrected for body size (β = −2.1 to −3.4 g/SD, p = 0.002 to 0.047). In a second independent cohort (n = 64), similar negative associations at two of these CpG sites, but positive associations at the two remaining sites, were observed; however, none of the relationships in this replication cohort achieved statistical significance. The maternal free 25(OH)‐vitamin D index was negatively associated with methylation at one of these RXRA CpG sites (β = −3.3 SD/unit, p = 0.03). Thus, perinatal epigenetic marking at the RXRA promoter region in umbilical cord was inversely associated with offspring size–corrected BMC in childhood. The potential mechanistic and functional significance of this finding remains a subject for further investigation. © 2014 American Society for Bone and Mineral Research.
Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the action of 1,25-dihydroxyvitamin D (1,25[OH]2 -vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual-energy X-ray absorptiometry, in a population-based mother-offspring cohort (Southampton Women's Survey). Relationships between maternal plasma 25-hydroxyvitamin D (25[OH]-vitamin D) concentrations and cord RXRA methylation were also investigated. In 230 children aged 4 years, a higher percent methylation at four of six RXRA CpG sites measured was correlated with lower offspring bone mineral content (BMC) corrected for body size (β = -2.1 to -3.4 g/SD, p = 0.002 to 0.047). In a second independent cohort (n = 64), similar negative associations at two of these CpG sites, but positive associations at the two remaining sites, were observed; however, none of the relationships in this replication cohort achieved statistical significance. The maternal free 25(OH)-vitamin D index was negatively associated with methylation at one of these RXRA CpG sites (β = -3.3 SD/unit, p = 0.03). Thus, perinatal epigenetic marking at the RXRA promoter region in umbilical cord was inversely associated with offspring size-corrected BMC in childhood. The potential mechanistic and functional significance of this finding remains a subject for further investigation.Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the action of 1,25-dihydroxyvitamin D (1,25[OH]2 -vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual-energy X-ray absorptiometry, in a population-based mother-offspring cohort (Southampton Women's Survey). Relationships between maternal plasma 25-hydroxyvitamin D (25[OH]-vitamin D) concentrations and cord RXRA methylation were also investigated. In 230 children aged 4 years, a higher percent methylation at four of six RXRA CpG sites measured was correlated with lower offspring bone mineral content (BMC) corrected for body size (β = -2.1 to -3.4 g/SD, p = 0.002 to 0.047). In a second independent cohort (n = 64), similar negative associations at two of these CpG sites, but positive associations at the two remaining sites, were observed; however, none of the relationships in this replication cohort achieved statistical significance. The maternal free 25(OH)-vitamin D index was negatively associated with methylation at one of these RXRA CpG sites (β = -3.3 SD/unit, p = 0.03). Thus, perinatal epigenetic marking at the RXRA promoter region in umbilical cord was inversely associated with offspring size-corrected BMC in childhood. The potential mechanistic and functional significance of this finding remains a subject for further investigation.
Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X Receptor-alpha (RXRA) is an essential cofactor in the action of 1,25(OH) 2 -vitamin D, and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual-energy X-ray absorptiometry, in a population-based mother-offspring cohort (Southampton Women’s Survey). Relationships between maternal plasma 25(OH)-vitamin D concentrations and cord RXRA methylation were also investigated. In 230 children aged 4 years, higher % methylation at 4 out of 6 RXRA CpG sites measured was correlated with lower offspring % bone mineral content (%BMC) (β=−0.02 to −0.04%/SD, p=0.002 to 0.043) and BMC corrected for body size (β=−2.1 to −3.4g/SD, p=0.002 to 0.047), with a further site associated with %BMC only. Similar relationships for %BMC were observed in a second independent cohort (n=64). Maternal free 25(OH)-vitamin D index was negatively associated with methylation at one of these RXRA CpG sites (β=−3.3 SD/unit, p=0.03). In addition to the mechanistic insights afforded by associations between maternal free 25(OH)-vitamin D index, RXRA methylation in umbilical cord DNA, and childhood BMC, such epigenetic marks in early life might represent novel biomarkers for adverse bone outcomes in the offspring.
Author Ntani, Georgia
Garratt, Emma
Inskip, Hazel M
Gluckman, Peter D
Godfrey, Keith M
Davies, Lucy
Lillycrop, Karen A
Cooper, Cyrus
Harvey, Nicholas C
Sheppard, Allan
Hanson, Mark A
McLean, Cameron
Murray, Robert
AuthorAffiliation 4 NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK
2 Liggins Institute, University of Auckland, New Zealand
3 AgResearch, Ruakura Research Centre, Hamilton, New Zealand
5 Southampton Institute of Developmental Sciences, University of Southampton, Southampton, UK
6 Singapore Institute for Clinical Sciences, Singapore
1 MRC Lifecourse Epidemiology Unit, University of Southampton, UK
AuthorAffiliation_xml – name: 3 AgResearch, Ruakura Research Centre, Hamilton, New Zealand
– name: 1 MRC Lifecourse Epidemiology Unit, University of Southampton, UK
– name: 6 Singapore Institute for Clinical Sciences, Singapore
– name: 4 NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/23907847$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1093/nar/11.5.1475
10.3945/jn.109.104653
10.1007/s001980170061
10.1093/nar/gkr602
10.1203/00006450-199704000-00022
10.1017/S0007114507352392
10.1210/jcem-63-4-954
10.2337/db12-1767
10.1093/ije/dyi202
10.1210/jc.2008-2146
10.1017/S2040174409990055
10.4161/epi.6.11.17942
10.1016/j.gene.2005.12.027
10.1096/fj.09-150490
10.1017/S0007114507894438
10.1073/pnas.0806560105
10.1038/nature08625
10.1359/jbmr.2001.16.9.1694
10.1056/NEJMra0708473
10.1093/ajcn/60.6.837
10.2337/db10-0979
10.1093/nar/23.23.4878
10.1016/S0140-6736(06)67922-1
10.1007/s00223-011-9554-5
10.1017/S000711450769196X
10.1038/ng.2249
10.1271/bbb.100684
10.1152/ajprenal.00076.2003
10.1038/ng.446
10.1210/jc.2007-0279
10.1007/s00198-010-1224-3
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Issue 3
Keywords METHYLATION
EPIGENETIC
RXRA
UMBILICAL CORD
DXA
VITAMIN D
Language English
License https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
2014 American Society for Bone and Mineral Research.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4436-dce522e175d7358626716e9648050614ba0c7296e93780be634642270fba95663
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
NCH and AS are joint first authors
Contributions
KAL and CC are joint senior authors
All authors contributed to manuscript authorship and preparation. NH oversaw the statistical analysis, wrote the draft manuscript and coordinated manuscript preparation. Laboratory analyses were performed by AS, CM, EG, RM and supervised by KL and AS. CC, KG, MH, PG and KL were responsible for the design and conception of the study. LD and GN undertook the statistical analyses. CC, HMI and KMG designed and implemented the Southampton Women’s Survey. CC oversaw the project and is guarantor.
OpenAccessLink https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.2056
PMID 23907847
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crossref_primary_10_1002_jbmr_2056
crossref_citationtrail_10_1002_jbmr_2056
wiley_primary_10_1002_jbmr_2056_JBMR2056
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PublicationTitle Journal of bone and mineral research
PublicationTitleAlternate J Bone Miner Res
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Publisher Oxford University Press
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References 2004; 286
2009; 41
2006; 35
1997; 41
2013; 62
2011; 60
2006; 372
2011; 75
2006
2003; 17
2008; 105
2011; 39
2007; 97
2008; 100
2011; 6
2008; 93
1994; 60
1983; 11
2009; 139
2012; 90
2010; 1
2010; 24
1986; 63
2009; 94
1995; 23
2002; 87
2009; 462
2011; 22
2008; 118
2008; 359
2001; 16
2001; 12
2012; 44
2006; 367
Harvey (2024020318555376600_jbmr2056-bib-0006) 2008; 93
Takeyama (2024020318555376600_jbmr2056-bib-0017) 2011; 75
Li (2024020318555376600_jbmr2056-bib-0015) 2006; 372
Ahuja (2024020318555376600_jbmr2056-bib-0016) 2003; 17
Brunton (2024020318555376600_jbmr2056-bib-0026) 1997; 41
Bikle (2024020318555376600_jbmr2056-bib-0022) 1986; 63
Park (2024020318555376600_jbmr2056-bib-0025) 2008; 118
Harvey (2024020318555376600_jbmr2056-bib-0019) 2012; 90
Gluckman (2024020318555376600_jbmr2056-bib-0009) 2008; 359
Burdge (2024020318555376600_jbmr2056-bib-0029) 2007; 97
Burdge (2024020318555376600_jbmr2056-bib-0013) 2009; 139
Godfrey (2024020318555376600_jbmr2056-bib-0003) 2001; 16
Kong (2024020318555376600_jbmr2056-bib-0010) 2009; 462
Quandt (2024020318555376600_jbmr2056-bib-0027) 1995; 23
Heijmans (2024020318555376600_jbmr2056-bib-0028) 2008; 105
Drake (2024020318555376600_jbmr2056-bib-0012) 2011; 6
Estrada (2024020318555376600_jbmr2056-bib-0008) 2012; 44
Prentice (2024020318555376600_jbmr2056-bib-0021) 1994; 60
Kranz (2024020318555376600_jbmr2056-bib-0024) 2011; 39
Cooper (2024020318555376600_jbmr2056-bib-0001) 2001; 12
Rivadeneira (2024020318555376600_jbmr2056-bib-0007) 2009; 41
Holick (2024020318555376600_jbmr2056-bib-0032) 2006
Javaid (2024020318555376600_jbmr2056-bib-0002) 2011; 22
Lillycrop (2024020318555376600_jbmr2056-bib-0030) 2008; 100
Lillycrop (2024020318555376600_jbmr2056-bib-0036) 2007; 97
Godfrey (2024020318555376600_jbmr2056-bib-0014) 2011; 60
Kip (2024020318555376600_jbmr2056-bib-0034) 2004; 286
Fall (2024020318555376600_jbmr2056-bib-0035) 2002; 87
Hanson (2024020318555376600_jbmr2056-bib-0011) 2013; 62
Harvey (2024020318555376600_jbmr2056-bib-0004) 2010; 1
Talens (2024020318555376600_jbmr2056-bib-0023) 2010; 24
Dignam (2024020318555376600_jbmr2056-bib-0020) 1983; 11
Sayers (2024020318555376600_jbmr2056-bib-0031) 2009; 94
Inskip (2024020318555376600_jbmr2056-bib-0018) 2006; 35
Javaid (2024020318555376600_jbmr2056-bib-0005) 2006; 367
Kovacs (2024020318555376600_jbmr2056-bib-0033) 2006
References_xml – volume: 17
  start-page: 29
  issue: 1
  year: 2003
  end-page: 45
  article-title: The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death
  publication-title: J Biol Regul Homeost Agents.
– volume: 23
  start-page: 4878
  issue: 23
  year: 1995
  end-page: 84
  article-title: MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data
  publication-title: Nucleic Acids Res.
– volume: 12
  start-page: 623
  issue: 8
  year: 2001
  end-page: 9
  article-title: Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study
  publication-title: Osteoporos Int.
– volume: 105
  start-page: 17046
  issue: 44
  year: 2008
  end-page: 9
  article-title: Persistent epigenetic differences associated with prenatal exposure to famine in humans
  publication-title: Proc Natl Acad Sci U S A.
– volume: 35
  start-page: 42
  issue: 1
  year: 2006
  end-page: 8
  article-title: Cohort profile: the Southampton Women's Survey
  publication-title: Int J Epidemiol.
– volume: 44
  start-page: 491
  issue: 5
  year: 2012
  end-page: 501
  article-title: Genome‐wide meta‐analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
  publication-title: Nat Genet.
– volume: 16
  start-page: 1694
  issue: 9
  year: 2001
  end-page: 703
  article-title: Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy
  publication-title: J Bone Miner Res.
– volume: 359
  start-page: 61
  issue: 1
  year: 2008
  end-page: 73
  article-title: Effect of in utero and early‐life conditions on adult health and disease
  publication-title: N Engl J Med.
– volume: 60
  start-page: 837
  issue: 6
  year: 1994
  end-page: 42
  article-title: Uncritical use of bone mineral density in absorptiometry may lead to size‐related artifacts in the identification of bone mineral determinants
  publication-title: Am J Clin Nutr.
– volume: 118
  start-page: 2316
  issue: 6
  year: 2008
  end-page: 24
  article-title: Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
  publication-title: J Clin Invest.
– volume: 462
  start-page: 868
  issue: 7275
  year: 2009
  end-page: 74
  article-title: Parental origin of sequence variants associated with complex diseases
  publication-title: Nature.
– volume: 6
  start-page: 1334
  issue: 11
  year: 2011
  end-page: 43
  article-title: Multigenerational programming in the glucocorticoid programmed rat is associated with generation‐specific and parent of origin effects
  publication-title: Epigenetics.
– volume: 1
  start-page: 35
  issue: 1
  year: 2010
  end-page: 41
  article-title: Maternal predictors of neonatal bone size and geometry: the Southampton Women's Survey
  publication-title: J Dev Orig Health Dis.
– volume: 39
  start-page: 8689
  issue: 20
  year: 2011
  end-page: 702
  article-title: Enhancers regulate progression of development in mammalian cells
  publication-title: Nucleic Acids Res.
– volume: 24
  start-page: 3135
  issue: 9
  year: 2010
  end-page: 44
  article-title: Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology
  publication-title: FASEB J.
– volume: 139
  start-page: 1054
  issue: 6
  year: 2009
  end-page: 60
  article-title: Folic acid supplementation during the juvenile‐pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition
  publication-title: J Nutr.
– volume: 367
  start-page: 36
  issue: 9504
  year: 2006
  end-page: 43
  article-title: Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
  publication-title: Lancet.
– volume: 97
  start-page: 435
  issue: 3
  year: 2007
  end-page: 9
  article-title: Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
  publication-title: Br J Nutr.
– start-page: 63
  year: 2006
  end-page: 7
– volume: 62
  start-page: 2984
  issue: 8
  year: 2013
  end-page: 91
  article-title: Strong parent‐of‐origin effects in the association of KCNQ1 variants with type 2 diabetes mellitus in American Indians
  publication-title: Diabetes.
– volume: 100
  start-page: 278
  issue: 2
  year: 2008
  end-page: 82
  article-title: Feeding pregnant rats a protein‐restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
  publication-title: Br J Nutr.
– volume: 94
  start-page: 765
  issue: 3
  year: 2009
  end-page: 71
  article-title: Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child
  publication-title: J Clin Endocrinol Metab.
– volume: 90
  start-page: 120
  issue: 2
  year: 2012
  end-page: 7
  article-title: Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content
  publication-title: Calcif Tissue Int.
– volume: 11
  start-page: 1475
  issue: 5
  year: 1983
  end-page: 89
  article-title: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
  publication-title: Nucleic Acids Res.
– volume: 97
  start-page: 1064
  issue: 6
  year: 2007
  end-page: 73
  article-title: Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein‐restricted diet during pregnancy suggests that reduced DNA methyltransferase‐1 expression is involved in impaired DNA methylation and changes in histone modifications
  publication-title: Br J Nutr.
– volume: 87
  start-page: 2001
  issue: 5
  year: 2002
  end-page: 7
  article-title: Does birth weight predict adult serum cortisol concentrations? Twenty‐four‐hour profiles in the United Kingdom 1920–1930 Hertfordshire Birth Cohort
  publication-title: J Clin Endocrinol Metab.
– volume: 63
  start-page: 954
  issue: 4
  year: 1986
  end-page: 9
  article-title: Assessment of the free fraction of 25‐hydroxyvitamin D in serum and its regulation by albumin and the vitamin D‐binding protein
  publication-title: J Clin Endocrinol Metab.
– start-page: 106
  year: 2006
  end-page: 14
– volume: 75
  start-page: 208
  issue: 2
  year: 2011
  end-page: 13
  article-title: The vitamin D3 1alpha‐hydroxylase gene and its regulation by active vitamin D3
  publication-title: Biosci Biotechnol Biochem.
– volume: 93
  start-page: 1676
  issue: 5
  year: 2008
  end-page: 81
  article-title: Paternal skeletal size predicts intrauterine bone mineral accrual
  publication-title: J Clin Endocrinol Metab.
– volume: 41
  start-page: 590
  year: 1997
  end-page: 6
  article-title: Improvement in the accuracy of dual energy x‐ray absorptiometry for whole body and regional analysis of body composition: validation using piglets and methodologic considerations in infants
  publication-title: Pediatr Res.
– volume: 22
  start-page: 69
  issue: 1
  year: 2011
  end-page: 73
  article-title: Growth in childhood predicts hip fracture risk in later life
  publication-title: Osteoporos Int.
– volume: 372
  start-page: 118
  year: 2006
  end-page: 27
  article-title: Identification and characterization of the human retinoid X receptor alpha gene promoter
  publication-title: Gene.
– volume: 41
  start-page: 1199
  issue: 11
  year: 2009
  end-page: 206
  article-title: Twenty bone‐mineral‐density loci identified by large‐scale meta‐analysis of genome‐wide association studies
  publication-title: Nat Genet.
– volume: 286
  start-page: F363
  issue: 2
  year: 2004
  end-page: 9
  article-title: Vitamin D3 upregulates plasma membrane Ca2+ ‐ATPase expression and potentiates apico‐basal Ca2+ flux in MDCK cells
  publication-title: Am J Physiol Renal Physiol.
– volume: 60
  start-page: 1528
  issue: 5
  year: 2011
  end-page: 34
  article-title: Epigenetic gene promoter methylation at birth is associated with child's later adiposity
  publication-title: Diabetes.
– volume: 11
  start-page: 1475
  issue: 5
  year: 1983
  ident: 2024020318555376600_jbmr2056-bib-0020
  article-title: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/11.5.1475
– volume: 139
  start-page: 1054
  issue: 6
  year: 2009
  ident: 2024020318555376600_jbmr2056-bib-0013
  article-title: Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition
  publication-title: J Nutr.
  doi: 10.3945/jn.109.104653
– volume: 118
  start-page: 2316
  issue: 6
  year: 2008
  ident: 2024020318555376600_jbmr2056-bib-0025
  article-title: Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
  publication-title: J Clin Invest.
– volume: 12
  start-page: 623
  issue: 8
  year: 2001
  ident: 2024020318555376600_jbmr2056-bib-0001
  article-title: Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study
  publication-title: Osteoporos Int.
  doi: 10.1007/s001980170061
– volume: 39
  start-page: 8689
  issue: 20
  year: 2011
  ident: 2024020318555376600_jbmr2056-bib-0024
  article-title: Enhancers regulate progression of development in mammalian cells
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr602
– volume: 41
  start-page: 590
  year: 1997
  ident: 2024020318555376600_jbmr2056-bib-0026
  article-title: Improvement in the accuracy of dual energy x-ray absorptiometry for whole body and regional analysis of body composition: validation using piglets and methodologic considerations in infants
  publication-title: Pediatr Res.
  doi: 10.1203/00006450-199704000-00022
– volume: 97
  start-page: 435
  issue: 3
  year: 2007
  ident: 2024020318555376600_jbmr2056-bib-0029
  article-title: Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114507352392
– volume: 63
  start-page: 954
  issue: 4
  year: 1986
  ident: 2024020318555376600_jbmr2056-bib-0022
  article-title: Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein
  publication-title: J Clin Endocrinol Metab.
  doi: 10.1210/jcem-63-4-954
– volume: 62
  start-page: 2984
  issue: 8
  year: 2013
  ident: 2024020318555376600_jbmr2056-bib-0011
  article-title: Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes mellitus in American Indians
  publication-title: Diabetes.
  doi: 10.2337/db12-1767
– volume: 35
  start-page: 42
  issue: 1
  year: 2006
  ident: 2024020318555376600_jbmr2056-bib-0018
  article-title: Cohort profile: the Southampton Women's Survey
  publication-title: Int J Epidemiol.
  doi: 10.1093/ije/dyi202
– volume: 87
  start-page: 2001
  issue: 5
  year: 2002
  ident: 2024020318555376600_jbmr2056-bib-0035
  article-title: Does birth weight predict adult serum cortisol concentrations? Twenty-four-hour profiles in the United Kingdom 1920–1930 Hertfordshire Birth Cohort
  publication-title: J Clin Endocrinol Metab.
– volume: 94
  start-page: 765
  issue: 3
  year: 2009
  ident: 2024020318555376600_jbmr2056-bib-0031
  article-title: Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child
  publication-title: J Clin Endocrinol Metab.
  doi: 10.1210/jc.2008-2146
– volume: 1
  start-page: 35
  issue: 1
  year: 2010
  ident: 2024020318555376600_jbmr2056-bib-0004
  article-title: Maternal predictors of neonatal bone size and geometry: the Southampton Women's Survey
  publication-title: J Dev Orig Health Dis.
  doi: 10.1017/S2040174409990055
– volume: 6
  start-page: 1334
  issue: 11
  year: 2011
  ident: 2024020318555376600_jbmr2056-bib-0012
  article-title: Multigenerational programming in the glucocorticoid programmed rat is associated with generation-specific and parent of origin effects
  publication-title: Epigenetics.
  doi: 10.4161/epi.6.11.17942
– volume: 372
  start-page: 118
  year: 2006
  ident: 2024020318555376600_jbmr2056-bib-0015
  article-title: Identification and characterization of the human retinoid X receptor alpha gene promoter
  publication-title: Gene.
  doi: 10.1016/j.gene.2005.12.027
– volume: 24
  start-page: 3135
  issue: 9
  year: 2010
  ident: 2024020318555376600_jbmr2056-bib-0023
  article-title: Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology
  publication-title: FASEB J.
  doi: 10.1096/fj.09-150490
– volume: 100
  start-page: 278
  issue: 2
  year: 2008
  ident: 2024020318555376600_jbmr2056-bib-0030
  article-title: Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114507894438
– volume: 105
  start-page: 17046
  issue: 44
  year: 2008
  ident: 2024020318555376600_jbmr2056-bib-0028
  article-title: Persistent epigenetic differences associated with prenatal exposure to famine in humans
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.0806560105
– volume: 462
  start-page: 868
  issue: 7275
  year: 2009
  ident: 2024020318555376600_jbmr2056-bib-0010
  article-title: Parental origin of sequence variants associated with complex diseases
  publication-title: Nature.
  doi: 10.1038/nature08625
– volume: 16
  start-page: 1694
  issue: 9
  year: 2001
  ident: 2024020318555376600_jbmr2056-bib-0003
  article-title: Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy
  publication-title: J Bone Miner Res.
  doi: 10.1359/jbmr.2001.16.9.1694
– start-page: 106
  volume-title: Primer on the metabolic bone diseases and mineral metabolism
  year: 2006
  ident: 2024020318555376600_jbmr2056-bib-0032
– volume: 359
  start-page: 61
  issue: 1
  year: 2008
  ident: 2024020318555376600_jbmr2056-bib-0009
  article-title: Effect of in utero and early-life conditions on adult health and disease
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMra0708473
– volume: 60
  start-page: 837
  issue: 6
  year: 1994
  ident: 2024020318555376600_jbmr2056-bib-0021
  article-title: Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants
  publication-title: Am J Clin Nutr.
  doi: 10.1093/ajcn/60.6.837
– volume: 60
  start-page: 1528
  issue: 5
  year: 2011
  ident: 2024020318555376600_jbmr2056-bib-0014
  article-title: Epigenetic gene promoter methylation at birth is associated with child's later adiposity
  publication-title: Diabetes.
  doi: 10.2337/db10-0979
– volume: 23
  start-page: 4878
  issue: 23
  year: 1995
  ident: 2024020318555376600_jbmr2056-bib-0027
  article-title: MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/23.23.4878
– start-page: 63
  volume-title: Primer on the metabolic bone diseases and mineral metabolism
  year: 2006
  ident: 2024020318555376600_jbmr2056-bib-0033
– volume: 17
  start-page: 29
  issue: 1
  year: 2003
  ident: 2024020318555376600_jbmr2056-bib-0016
  article-title: The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death
  publication-title: J Biol Regul Homeost Agents.
– volume: 367
  start-page: 36
  issue: 9504
  year: 2006
  ident: 2024020318555376600_jbmr2056-bib-0005
  article-title: Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
  publication-title: Lancet.
  doi: 10.1016/S0140-6736(06)67922-1
– volume: 90
  start-page: 120
  issue: 2
  year: 2012
  ident: 2024020318555376600_jbmr2056-bib-0019
  article-title: Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content
  publication-title: Calcif Tissue Int.
  doi: 10.1007/s00223-011-9554-5
– volume: 97
  start-page: 1064
  issue: 6
  year: 2007
  ident: 2024020318555376600_jbmr2056-bib-0036
  article-title: Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications
  publication-title: Br J Nutr.
  doi: 10.1017/S000711450769196X
– volume: 44
  start-page: 491
  issue: 5
  year: 2012
  ident: 2024020318555376600_jbmr2056-bib-0008
  article-title: Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
  publication-title: Nat Genet.
  doi: 10.1038/ng.2249
– volume: 75
  start-page: 208
  issue: 2
  year: 2011
  ident: 2024020318555376600_jbmr2056-bib-0017
  article-title: The vitamin D3 1alpha-hydroxylase gene and its regulation by active vitamin D3
  publication-title: Biosci Biotechnol Biochem.
  doi: 10.1271/bbb.100684
– volume: 286
  start-page: F363
  issue: 2
  year: 2004
  ident: 2024020318555376600_jbmr2056-bib-0034
  article-title: Vitamin D3 upregulates plasma membrane Ca2+ -ATPase expression and potentiates apico-basal Ca2+ flux in MDCK cells
  publication-title: Am J Physiol Renal Physiol.
  doi: 10.1152/ajprenal.00076.2003
– volume: 41
  start-page: 1199
  issue: 11
  year: 2009
  ident: 2024020318555376600_jbmr2056-bib-0007
  article-title: Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
  publication-title: Nat Genet.
  doi: 10.1038/ng.446
– volume: 93
  start-page: 1676
  issue: 5
  year: 2008
  ident: 2024020318555376600_jbmr2056-bib-0006
  article-title: Paternal skeletal size predicts intrauterine bone mineral accrual
  publication-title: J Clin Endocrinol Metab.
  doi: 10.1210/jc.2007-0279
– volume: 22
  start-page: 69
  issue: 1
  year: 2011
  ident: 2024020318555376600_jbmr2056-bib-0002
  article-title: Growth in childhood predicts hip fracture risk in later life
  publication-title: Osteoporos Int.
  doi: 10.1007/s00198-010-1224-3
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Snippet ABSTRACT Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid‐X receptor‐alpha (RXRA) is an essential...
Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the...
Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X Receptor-alpha (RXRA) is an essential cofactor in the...
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SourceType Open Access Repository
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StartPage 600
SubjectTerms Adult
Bone Density
Child
Child, Preschool
CpG Islands
DNA Methylation
DXA
Electrophoretic Mobility Shift Assay
EPIGENETIC
Female
Humans
Male
METHYLATION
Promoter Regions, Genetic
Prospective Studies
Retinoid X Receptor alpha - genetics
RXRA
UMBILICAL CORD
VITAMIN D
Vitamin D - analogs & derivatives
Vitamin D - blood
Title Childhood Bone Mineral Content Is Associated With Methylation Status of the RXRA Promoter at Birth
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjbmr.2056
https://www.ncbi.nlm.nih.gov/pubmed/23907847
https://www.proquest.com/docview/1500128570
https://www.proquest.com/docview/1504454876
https://pubmed.ncbi.nlm.nih.gov/PMC3836689
Volume 29
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