Serotonin, β‐amyloid, and cognition in Parkinson disease

• Published in: Annals of neurology Vol. 83; no. 5; pp. 994 - 1002
• Main Authors: Kotagal, Vikas, Spino, Cathie, Bohnen, Nicolaas I., Koeppe, Robert, Albin, Roger L.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2018
• Subjects: Baseline studies; Benzonitrile; Cerebral cortex; Cerebrospinal fluid; Cognition; Cognitive ability; Computed tomography; Denervation; Disease control; Dopamine; Dopamine transporter; Drugs; Innervation; Mental depression; Metabolism; Movement disorders; Neostriatum; Neurodegenerative diseases; Neuroimaging; Neurotransmission; Parkinson's disease; Photon emission; Positron emission; Positron emission tomography; Risk; Secretase; Serotonin; Single photon emission computed tomography; Statistical models; Tomography; β-Amyloid

Objective Serotoninergic neurotransmission may modulate β‐amyloid peptide (Aβ) metabolism through upregulation of α‐secretase. Early Parkinson disease (PD) shows variable serotoninergic denervation, which may impact Aβ deposition. Methods We conducted 3 analyses to explore associations between serot...