Exome sequence analysis and follow up genotyping implicates rare ULK1 variants to be involved in susceptibility to schizophrenia

• Published in: Annals of human genetics Vol. 82; no. 2; pp. 88 - 92
• Main Authors: Al Eissa, Mariam M., Fiorentino, Alessia, Sharp, Sally I., O'Brien, Niamh L., Wolfe, Kate, Giaroli, Giovanni, Curtis, David, Bass, Nicholas J., McQuillin, Andrew
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2018; John Wiley and Sons Inc
• Subjects: association; Autophagy; Autophagy-Related Protein-1 Homolog - genetics; burden analysis; Case-Control Studies; Exome; Exome Sequencing; Genotype; Genotyping; Humans; Intracellular Signaling Peptides and Proteins - genetics; Introns; Kinases; Mental disorders; Mutation, Missense; olanzapine; Original; Phagocytosis; Schizophrenia; Schizophrenia - genetics; Signal transduction; Sweden; TOR protein; Sweden; olanzapine; association; burden analysis

Summary Schizophrenia (SCZ) is a severe, highly heritable psychiatric disorder. Elucidation of the genetic architecture of the disorder will facilitate greater understanding of the altered underlying neurobiological mechanisms. The aim of this study was to identify likely aetiological variants in su...