Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss

• Published in: Journal of periodontal research Vol. 54; no. 4; pp. 444 - 452
• Main Authors: Menzel, Lorenzo P., Ruddick, Willam, Chowdhury, Mobaswar H., Brice, David C., Clance, Ryan, Porcelli, Emily, Ryan, Lisa K., Lee, Jungnam, Yilmaz, Özlem, Kirkwood, Keith L., McMahon, Laura, Tran, Amy, Diamond, Gill
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2019
• Subjects: Alveolar bone; Alveolar Bone Loss - immunology; Alveolar Bone Loss - physiopathology; Animals; Antimicrobial agents; antimicrobial peptide; Antimicrobial peptides; Bone loss; Calcifediol - pharmacology; Calcitriol; Cell lines; Cells, Cultured; Dietary restrictions; Enzyme-linked immunosorbent assay; Epithelial cells; Epithelium; Gingiva; Gingiva - physiology; Gum disease; Humans; Hydroxylase; Inflammation; Inflammation - immunology; Inflammation - physiopathology; Interleukin-1alpha - immunology; Intracellular; Mice; Mice, Inbred C57BL; Nutrient deficiency; periodontal disease; Periodontal diseases; Porphyromonas gingivalis; Ribonucleic acid; RNA; Topical application; Vitamin D; Vitamin D - pharmacology; Vitamin D3; Vitamin deficiency; Vitamins - pharmacology; antimicrobial peptide; inflammation; vitamin D; periodontal disease

Background and Objective Both chronic and aggressive periodontal disease are associated with vitamin D deficiency. The active form of vitamin D, 1,25(OH)2D3, induces the expression of the antimicrobial peptide LL‐37 and innate immune mediators in cultured human gingival epithelial cells (GECs). The...