Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis

• Published in: Brain pathology (Zurich, Switzerland) Vol. 28; no. 5; pp. 656 - 662
• Main Authors: Korshunov, Andrey, Chavez, Lukas, Sharma, Tanvi, Ryzhova, Marina, Schrimpf, Daniel, Stichel, Damian, Capper, David, Sturm, Dominik, Kool, Marcel, Habel, Antje, Kleinschmidt‐DeMasters, Bette K., Rosenblum, Marc, Absalyamova, Oksana, Golanov, Andrey, Lichter, Peter, Pfister, Stefan M., Jones, David T.W., Perry, Arie, von Deimling, Andreas
• Format: Journal Article
• Language: English
• Published: Switzerland John Wiley & Sons, Inc 01.09.2018; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Adults; Aged; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Child; Child, Preschool; Children; Cohort Studies; Computational Biology; Copy number; cytogenetic prognostic; Data processing; Diagnostic systems; DNA Copy Number Variations; DNA methylation; Epigenesis, Genetic; epithelioid; Female; Gene sequencing; Genomes; Glioblastoma; Glioblastoma - genetics; Glioblastoma - metabolism; Glioblastoma - mortality; Glioblastoma - pathology; Humans; Male; methylation; Middle Aged; Mutation; Neoplasms; Older people; Pediatrics; pleomorphic xanthoastrocytoma; Prognosis; Proto-Oncogene Proteins B-raf - genetics; Proto-Oncogene Proteins B-raf - metabolism; subgroup; survival; Tumors; Young Adult; Young adults; epithelioid; glioblastoma; subgroup; cytogenetic prognostic; methylation; survival; pleomorphic xanthoastrocytoma

Epithelioid glioblastoma (eGBM) is a newly defined and rare GBM variant in the current WHO 2016 classification. BRAF V600E mutation is overrepresented in these tumors and there is known some morphological overlap with anaplastic epithelioid PXA (ePXA). In order to further elucidate this diagnostic c...