Influence of Genetic Polymorphisms on Clopidogrel Response and Clinical Outcomes in Patients with Acute Ischemic Stroke CYP2C19 Genotype on Clopidogrel Response

• Published in: CNS neuroscience & therapeutics Vol. 21; no. 9; pp. 692 - 697
• Main Authors: Han, Yan, Lv, Hui‐Hui, Liu, Xu, Dong, Qiang, Yang, Xiao‐Li, Li, Shi‐Xu, Wu, Shuai, Jiang, Jian‐Ming, Luo, Zheng, Zhu, De‐Sheng, Zhang, Yi, Zheng, Yi, Guan, Yang‐Tai, Xu, Jian‐Feng
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.09.2015; John Wiley and Sons Inc
• Subjects: Aged; Biomarkers, Pharmacological; Brain Ischemia - drug therapy; Brain Ischemia - genetics; Cardiology; Clinical outcomes; Clopidogrel; CYP2C19; Cytochrome P-450 CYP2C19 - genetics; Female; Follow-Up Studies; Genotype; Genotype & phenotype; Humans; Ischemic stroke; Male; Original; Platelet Aggregation Inhibitors - therapeutic use; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Random Allocation; Stroke; Stroke - drug therapy; Stroke - genetics; The VerifyNow P2Y12 test; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Treatment Outcome; Clopidogrel; Ischemic stroke; CYP2C19; The VerifyNow P2Y12 test

Summary Objectives This study sought to evaluate the influence of the genetic polymorphisms on platelet reactivity and clinical outcomes in acute ischemic stroke patients taking clopidogrel. Background Little research has been published on relationships between genetic polymorphisms, platelet reacti...