Variety of endosomal TLRs and Interferons (IFN‐α, IFN‐β, IFN‐γ) expression profiles in patients with SLE, SSc and MCTD

• Published in: Clinical and experimental immunology Vol. 204; no. 1; pp. 49 - 63
• Main Authors: Paradowska‐Gorycka, A., Wajda, A., Stypinska, B., Walczuk, E., Rzeszotarska, E., Walczyk, M., Haladyj, E., Romanowska‐Prochnicka, K., Felis‐Giemza, A., Lewandowska, A., Olesińska, M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2021; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers; connective tissue disease; Connective tissue diseases; Endosomes - genetics; Endosomes - metabolism; expression; Female; Gene expression; Gene Expression Profiling - methods; Humans; Interferon; Interferon-alpha - blood; Interferon-alpha - genetics; Interferon-alpha - metabolism; Interferon-beta - blood; Interferon-beta - genetics; Interferon-beta - metabolism; Interferon-gamma - blood; Interferon-gamma - genetics; Interferon-gamma - metabolism; Interferons - blood; Interferons - genetics; Interferons - metabolism; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - metabolism; Male; Middle Aged; Mixed connective tissue disease; Mixed Connective Tissue Disease - blood; Mixed Connective Tissue Disease - genetics; Mixed Connective Tissue Disease - metabolism; Original; pathogenesis; Scleroderma; Scleroderma, Systemic - blood; Scleroderma, Systemic - genetics; Scleroderma, Systemic - metabolism; Systemic lupus erythematosus; Systemic sclerosis; TLR; Toll-Like Receptor 3 - blood; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 3 - metabolism; Toll-Like Receptor 7 - blood; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - metabolism; Toll-Like Receptor 8 - blood; Toll-Like Receptor 8 - genetics; Toll-Like Receptor 8 - metabolism; Toll-Like Receptor 9 - blood; Toll-Like Receptor 9 - genetics; Toll-Like Receptor 9 - metabolism; Toll-like receptors; Toll-Like Receptors - blood; Toll-Like Receptors - genetics; Toll-Like Receptors - metabolism; Young Adult; pathogenesis; expression; TLR; interferon; connective tissue disease

Summary We investigated Toll‐like receptor (TLR)‐3/‐7/‐8/‐9 and interferon (IFN)‐α/β/γ mRNA expression in whole blood and serum IFN‐α/β/γ levels in patients with mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) and in healthy subjects to assess...