The anti‐hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes‐associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy

• Published in: British journal of pharmacology Vol. 174; no. 10; pp. 1147 - 1160
• Main Authors: Ge, Maoxu, Liu, Hong, Zhang, Yixuan, Li, Naren, Zhao, Shuangshuang, Zhao, Wuli, Zhen, Yongzhan, Yu, Jianzhong, He, Hongwei, Shao, Rong‐guang
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2017; John Wiley and Sons Inc
• Subjects: Animals; Apoptosis Regulatory Proteins - antagonists & inhibitors; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Autophagy; Autophagy - drug effects; Bile; Bile ducts; Bile Ducts - pathology; Bile Ducts - surgery; Cell Line; Chinese medicine; Collagen; Collagen (type I); Connective tissue growth factor; Dose-Response Relationship, Drug; Fibrosis; Gelatinase A; Hepatic Stellate Cells - drug effects; Humans; Immunofluorescence; Ligation; Lipophilic; Liver; Liver Cirrhosis - drug therapy; Liver Cirrhosis - genetics; Liver Cirrhosis - pathology; Male; Molecular Structure; Nuclear transport; Phagocytosis; Phenanthrenes - administration & dosage; Phenanthrenes - chemistry; Phenanthrenes - pharmacology; Proteins; Rats; Rats, Sprague-Dawley; Research Paper; Research Papers; Rodents; Salvia miltiorrhiza; Stellate cells; Structure-Activity Relationship; Survivin; Tissue analysis; Traditional Chinese medicine; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Transcription Factors - metabolism; Transforming growth factor-b1; Translocation; Yes-associated protein

Background and Purpose Dihydrotanshinone I (DHI), a lipophilic component of traditional Chinese medicine Salvia miltiorrhiza Bunge, has various therapeutic effects. We investigated the anti‐fibrotic effect of DHI and its underlying mechanisms in vitro and in vivo. Experimental Approach Rats subjecte...