Accounting for the role of hematocrit in between‐subject variations of MRI‐derived baseline cerebral hemodynamic parameters and functional BOLD responses

Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between‐subject variation of Hct thus causes variation in task‐based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1...

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Published inHuman brain mapping Vol. 39; no. 1; pp. 344 - 353
Main Authors Xu, Feng, Li, Wenbo, Liu, Peiying, Hua, Jun, Strouse, John J., Pekar, James J., Lu, Hanzhang, van Zijl, Peter C.M., Qin, Qin
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.01.2018
John Wiley and Sons Inc
Subjects
Adult
Biological Variation, Individual
Blood flow
BOLD
Brain
Brain - diagnostic imaging
Brain - physiology
Brain Mapping
CBF
Cerebral blood flow
Cerebrovascular Circulation - physiology
CMRO2
Correlation
DO2
Female
Functional magnetic resonance imaging
Hct
Hematocrit
Humans
Linear Models
Magnetic Resonance Imaging
Male
Metabolic rate
MRI
OEF
Oxygen
Oxygen - blood
Perfusion
Variation
Visual Perception - physiology
Visual tasks
OEF
MRI
CBF
DO2
Hct
BOLD
CMRO2
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Abstract Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between‐subject variation of Hct thus causes variation in task‐based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by comparison with the conventional lab test. Together with CBF measured using phase‐contrast MRI, this noninvasive estimation of Hct, instead of using a population‐averaged Hct value, enabled more individual determination of oxygen delivery (DO2), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2). The inverse correlation of CBF and Hct explained about 80% of between‐subject variation of CBF in this relatively uniform cohort of subjects, as expected based on the regulation of DO2 to maintain constant CMRO2. Furthermore, we compared the relationships of visual task‐evoked BOLD response with Hct and CBF. We showed that Hct and CBF contributed 22%–33% of variance in BOLD signal and removing the positive correlation with Hct and negative correlation with CBF allowed normalization of BOLD signal with 16%–22% lower variability. The results of this study suggest that adjustment for Hct effects is useful for studies of MRI perfusion and BOLD fMRI. Hum Brain Mapp 39:344–353, 2018. © 2017 Wiley Periodicals, Inc.
AbstractList Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by comparison with the conventional lab test. Together with CBF measured using phase-contrast MRI, this noninvasive estimation of Hct, instead of using a population-averaged Hct value, enabled more individual determination of oxygen delivery (DO2 ), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2 ). The inverse correlation of CBF and Hct explained about 80% of between-subject variation of CBF in this relatively uniform cohort of subjects, as expected based on the regulation of DO2 to maintain constant CMRO2 . Furthermore, we compared the relationships of visual task-evoked BOLD response with Hct and CBF. We showed that Hct and CBF contributed 22%-33% of variance in BOLD signal and removing the positive correlation with Hct and negative correlation with CBF allowed normalization of BOLD signal with 16%-22% lower variability. The results of this study suggest that adjustment for Hct effects is useful for studies of MRI perfusion and BOLD fMRI. Hum Brain Mapp 39:344-353, 2018. © 2017 Wiley Periodicals, Inc.Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by comparison with the conventional lab test. Together with CBF measured using phase-contrast MRI, this noninvasive estimation of Hct, instead of using a population-averaged Hct value, enabled more individual determination of oxygen delivery (DO2 ), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2 ). The inverse correlation of CBF and Hct explained about 80% of between-subject variation of CBF in this relatively uniform cohort of subjects, as expected based on the regulation of DO2 to maintain constant CMRO2 . Furthermore, we compared the relationships of visual task-evoked BOLD response with Hct and CBF. We showed that Hct and CBF contributed 22%-33% of variance in BOLD signal and removing the positive correlation with Hct and negative correlation with CBF allowed normalization of BOLD signal with 16%-22% lower variability. The results of this study suggest that adjustment for Hct effects is useful for studies of MRI perfusion and BOLD fMRI. Hum Brain Mapp 39:344-353, 2018. © 2017 Wiley Periodicals, Inc.
Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between‐subject variation of Hct thus causes variation in task‐based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by comparison with the conventional lab test. Together with CBF measured using phase‐contrast MRI, this noninvasive estimation of Hct, instead of using a population‐averaged Hct value, enabled more individual determination of oxygen delivery (DO2), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2). The inverse correlation of CBF and Hct explained about 80% of between‐subject variation of CBF in this relatively uniform cohort of subjects, as expected based on the regulation of DO2 to maintain constant CMRO2. Furthermore, we compared the relationships of visual task‐evoked BOLD response with Hct and CBF. We showed that Hct and CBF contributed 22%–33% of variance in BOLD signal and removing the positive correlation with Hct and negative correlation with CBF allowed normalization of BOLD signal with 16%–22% lower variability. The results of this study suggest that adjustment for Hct effects is useful for studies of MRI perfusion and BOLD fMRI. Hum Brain Mapp 39:344–353, 2018. © 2017 Wiley Periodicals, Inc.
Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between‐subject variation of Hct thus causes variation in task‐based BOLD fMRI signal changes. We first verified in healthy volunteers ( n  = 12) that Hct values can be derived reliably from venous blood T 1 values by comparison with the conventional lab test. Together with CBF measured using phase‐contrast MRI, this noninvasive estimation of Hct, instead of using a population‐averaged Hct value, enabled more individual determination of oxygen delivery (DO 2 ), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO 2 ). The inverse correlation of CBF and Hct explained about 80% of between‐subject variation of CBF in this relatively uniform cohort of subjects, as expected based on the regulation of DO 2 to maintain constant CMRO 2 . Furthermore, we compared the relationships of visual task‐evoked BOLD response with Hct and CBF. We showed that Hct and CBF contributed 22%–33% of variance in BOLD signal and removing the positive correlation with Hct and negative correlation with CBF allowed normalization of BOLD signal with 16%–22% lower variability. The results of this study suggest that adjustment for Hct effects is useful for studies of MRI perfusion and BOLD fMRI. Hum Brain Mapp 39:344–353, 2018 . © 2017 Wiley Periodicals, Inc.
Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T values by comparison with the conventional lab test. Together with CBF measured using phase-contrast MRI, this noninvasive estimation of Hct, instead of using a population-averaged Hct value, enabled more individual determination of oxygen delivery (DO ), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO ). The inverse correlation of CBF and Hct explained about 80% of between-subject variation of CBF in this relatively uniform cohort of subjects, as expected based on the regulation of DO to maintain constant CMRO . Furthermore, we compared the relationships of visual task-evoked BOLD response with Hct and CBF. We showed that Hct and CBF contributed 22%-33% of variance in BOLD signal and removing the positive correlation with Hct and negative correlation with CBF allowed normalization of BOLD signal with 16%-22% lower variability. The results of this study suggest that adjustment for Hct effects is useful for studies of MRI perfusion and BOLD fMRI. Hum Brain Mapp 39:344-353, 2018. © 2017 Wiley Periodicals, Inc.
Author Strouse, John J.
Liu, Peiying
Qin, Qin
Xu, Feng
Hua, Jun
Pekar, James J.
Lu, Hanzhang
van Zijl, Peter C.M.
Li, Wenbo
AuthorAffiliation 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore Maryland
4 Division of Hematology, Department of Medicine Duke University Durham North Carolina
3 Developing Brain Research Lab Children's National Medical Center Washington DC Washington
1 The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research Johns Hopkins University School of Medicine Baltimore Maryland
AuthorAffiliation_xml – name: 1 The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research Johns Hopkins University School of Medicine Baltimore Maryland
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Keywords OEF
MRI
CBF
DO2
Hct
BOLD
CMRO2
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Notes Feng Xu and Wenbo Li contributed equally to this work.
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Snippet Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between‐subject variation of Hct thus causes variation in...
Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in...
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StartPage 344
SubjectTerms Adult
Biological Variation, Individual
Blood flow
BOLD
Brain
Brain - diagnostic imaging
Brain - physiology
Brain Mapping
CBF
Cerebral blood flow
Cerebrovascular Circulation - physiology
CMRO2
Correlation
DO2
Female
Functional magnetic resonance imaging
Hct
Hematocrit
Humans
Linear Models
Magnetic Resonance Imaging
Male
Metabolic rate
MRI
OEF
Oxygen
Oxygen - blood
Perfusion
Variation
Visual Perception - physiology
Visual tasks
Title Accounting for the role of hematocrit in between‐subject variations of MRI‐derived baseline cerebral hemodynamic parameters and functional BOLD responses
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhbm.23846
https://www.ncbi.nlm.nih.gov/pubmed/29024300
https://www.proquest.com/docview/1972997621
https://www.proquest.com/docview/1953293588
https://pubmed.ncbi.nlm.nih.gov/PMC5718957
Volume 39
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