Natural products and their derivatives: Promising modulators of tumor immunotherapy

A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulato...

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Published inJournal of leukocyte biology Vol. 108; no. 2; pp. 493 - 508
Main Authors Deng, Li‐Juan, Qi, Ming, Li, Nan, Lei, Yu‐He, Zhang, Dong‐Mei, Chen, Jia‐Xu
Format Journal Article
LanguageEnglish
Published United States John Wiley and Sons Inc 01.08.2020
Subjects
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
cardiotonic steroids
Humans
Immunologic Factors - chemistry
Immunologic Factors - pharmacology
Immunologic Factors - therapeutic use
Immunomodulation - drug effects
Immunotherapy - adverse effects
Immunotherapy - methods
Neoplasms - immunology
Neoplasms - therapy
polyphenolics
polysaccharides
Review
terpenoids
Treatment Outcome
Tregs
tumor immunotherapy
polyphenolics
polysaccharides
cardiotonic steroids
terpenoids
Tregs
tumor immunotherapy
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Abstract A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid‐derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF‐κB, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research. This review aims to summarize the integrated research progress of natural products (e.g. curcumin) on the tumor immunotherapy and key intracellular pathways.
AbstractList A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid-derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF-κB, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research.A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid-derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF-κB, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research.
A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid-derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF-κB, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research.
A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid‐derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF‐κB, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research. This review aims to summarize the integrated research progress of natural products (e.g. curcumin) on the tumor immunotherapy and key intracellular pathways.
Author Li, Nan
Qi, Ming
Chen, Jia‐Xu
Deng, Li‐Juan
Lei, Yu‐He
Zhang, Dong‐Mei
AuthorAffiliation 1 Formula‐Pattern Research Center School of Traditional Chinese Medicine Jinan University Guangzhou China
2 Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Jinan University Guangzhou China
3 Department of Pharmacy Shenzhen Hospital of Guangzhou University of Chinese Medicine Shenzhen China
AuthorAffiliation_xml – name: 1 Formula‐Pattern Research Center School of Traditional Chinese Medicine Jinan University Guangzhou China
– name: 3 Department of Pharmacy Shenzhen Hospital of Guangzhou University of Chinese Medicine Shenzhen China
– name: 2 Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Jinan University Guangzhou China
Author_xml – sequence: 1
  givenname: Li‐Juan
  surname: Deng
  fullname: Deng, Li‐Juan
  organization: Jinan University
– sequence: 2
  givenname: Ming
  surname: Qi
  fullname: Qi, Ming
  organization: Jinan University
– sequence: 3
  givenname: Nan
  surname: Li
  fullname: Li, Nan
  organization: Jinan University
– sequence: 4
  givenname: Yu‐He
  surname: Lei
  fullname: Lei, Yu‐He
  organization: Shenzhen Hospital of Guangzhou University of Chinese Medicine
– sequence: 5
  givenname: Dong‐Mei
  surname: Zhang
  fullname: Zhang, Dong‐Mei
  organization: Jinan University
– sequence: 6
  givenname: Jia‐Xu
  orcidid: 0000-0002-5570-6233
  surname: Chen
  fullname: Chen, Jia‐Xu
  email: chenjiaxu@hotmail.com
  organization: Jinan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32678943$$D View this record in MEDLINE/PubMed
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Keywords polyphenolics
polysaccharides
cardiotonic steroids
terpenoids
Tregs
tumor immunotherapy
Language English
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Snippet A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the...
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SubjectTerms Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
cardiotonic steroids
Humans
Immunologic Factors - chemistry
Immunologic Factors - pharmacology
Immunologic Factors - therapeutic use
Immunomodulation - drug effects
Immunotherapy - adverse effects
Immunotherapy - methods
Neoplasms - immunology
Neoplasms - therapy
polyphenolics
polysaccharides
Review
terpenoids
Treatment Outcome
Tregs
tumor immunotherapy
Title Natural products and their derivatives: Promising modulators of tumor immunotherapy
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2FJLB.3MR0320-444R
https://www.ncbi.nlm.nih.gov/pubmed/32678943
https://www.proquest.com/docview/2424991037
https://pubmed.ncbi.nlm.nih.gov/PMC7496826
Volume 108
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