Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus

• Published in: American journal of reproductive immunology (1989) Vol. 81; no. 3; pp. e13075 - n/a
• Main Authors: Sutton, Jessica A., Rogers, Lisa M., Dixon, Beverly R.E.A., Kirk, Leslie, Doster, Ryan, Algood, Holly M., Gaddy, Jennifer A., Flaherty, Rebecca, Manning, Shannon D., Aronoff, David M.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.03.2019
• Subjects: Cell activation; Cells, Cultured; Chorioamnionitis; cytokine; Cytokines - metabolism; Female; Fetuses; Gene expression; Group B Streptococcus; Humans; Immune response; infection; inflammasome; Inflammasomes; Inflammasomes - metabolism; Inflammation; Inflammation - immunology; Kinases; Macrophages; Macrophages - immunology; NF-kappa B - metabolism; NF-κB protein; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Phenotypes; Placenta; Placenta - immunology; placental macrophage; Pregnancy; Protein kinase; Protein Kinase C - immunology; Reproductive system; Signal Transduction; Streptococcal Infections - immunology; Streptococcus; Streptococcus agalactiae - physiology; Streptococcus infections; Tumor necrosis factor-α; cytokine; placental macrophage; infection; inflammation; Group B Streptococcus; inflammasome

Problem During pregnancy, Group B Streptococcus (GBS) can infect fetal membranes to cause chorioamnionitis, resulting in adverse pregnancy outcomes. Macrophages are the primary resident phagocyte in extraplacental membranes. Protein kinase D (PKD) was recently implicated in mediating pro‐inflammator...