The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity - Avdoshina, Valeria; Caragher, Seamus P.; Wenzel, Erin D.; Taraballi, Francesca; Mocchetti, Italo; Harry, Gaylia Jean (Journal of neurochemistry, 2017)
Keywords: Acetylation; AIDS Dementia Complex - pathology; Animals; Cells, Cultured; Cerebral cortex; Cognition; Disorders; Dynamic stability; Glycoprotein gp120; HAND; Helix‐A peptide; HIV; HIV Envelope Protein gp120 - pharmacology; HIV Envelope Protein gp120 - toxicity; HIV transgenic rats; Homeostasis; Human immunodeficiency virus; Humans; In vitro methods and tests; In vivo methods and tests; Interleukin 1; Interleukin-1beta - biosynthesis; Interleukin-1beta - genetics; Male; Microglia; Microtubules; Microtubules - drug effects; mRNA; Neurons - metabolism; Neurotoxicity; Polymerization; Post-translation; Protein Processing, Post-Translational; Pruning; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Rodents; Translation; Tubulin; Tubulin - metabolism; Tumor Necrosis Factor-alpha - biosynthesis; Tumor Necrosis Factor-alpha - genetics; Viral envelope proteins; Viruses; HIV transgenic rats; Helix-A peptide; microtubules; microglia; HAND