Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations

• Published in: Journal of viral hepatitis Vol. 28; no. 8; pp. 1110 - 1120
• Main Authors: Mokaya, Jolynne, Vasylyeva, Tetyana I., Barnes, Eleanor, Ansari, M. Azim, Pybus, Oliver G., Matthews, Philippa C.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2021; John Wiley and Sons Inc
• Subjects: Africa; Age composition; Antiretroviral drugs; Antiviral drugs; Disease resistance; Drug resistance; entecavir; epidemiology; Genotype & phenotype; Genotypes; HBV; HBV vaccine; Hepatitis B; lamivudine; Morbidity; Mutation; NAs; NUCs; Original; Phylogenetics; Phylogeny; prevention; RAMs; resistance; TDF; tenofovir; therapy; Vaccines; NAs; tenofovir; therapy; Africa; entecavir; resistance; epidemiology; NUCs; RAMs; TDF; HBV vaccine; HBV; prevention; lamivudine

Vaccination and anti‐viral therapy with nucleos(t)ide analogues (NAs) are key approaches to reducing the morbidity, mortality and transmission of hepatitis B virus (HBV) infection. However, the efficacy of these interventions may be reduced by the emergence of drug resistance‐associated mutations (R...