Changes in Skeletal Microstructure Through Four Continuous Years of rhPTH(1–84) Therapy in Hypoparathyroidism

• Published in: Journal of bone and mineral research Vol. 35; no. 7; pp. 1274 - 1281
• Main Authors: Cusano, Natalie E, Rubin, Mishaela R, Williams, John M, Agarwal, Sanchita, Tabacco, Gaia, Tay, Donovan, Majeed, Rukshana, Omeragic, Beatriz, Bilezikian, John P
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2020; Wiley Subscription Services, Inc
• Subjects: Biopsy; Bone density; BONE MICROARCHITECTURE; Bone mineral density; Bone remodeling; Computed tomography; Dual energy X-ray absorptiometry; HIGH‐RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY (HR‐PQCT); HYPOPARATHYROIDISM; Parathyroid hormone; Porosity; Radius; Spine (lumbar); Tibia; BONE MICROARCHITECTURE; HYPOPARATHYROIDISM; HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY (HR-PQCT)

ABSTRACT Bone remodeling is reduced in hypoparathyroidism, resulting in increased areal bone mineral density (BMD) by dual‐energy X‐ray absorptiometry (DXA) and abnormal skeletal indices by transiliac bone biopsy. We have now studied skeletal microstructure by high‐resolution peripheral quantitative...