Positive reactions to gold sodium thiosulfate in patch test panels (TRUE Test) in Japan: A multicentre study

• Published in: Contact dermatitis Vol. 80; no. 2; pp. 114 - 117
• Main Authors: Suzuki, Kayoko, Yagami, Akiko, Ito, Akiko, Kato, Atsuko, Miyazawa, Hitoshi, Kanto, Hiromi, Matsunaga, Kayoko
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2019; Wiley Subscription Services, Inc
• Subjects: active sensitization; Adolescent; Adult; Aged; Aged, 80 and over; Child; Dermatitis, Allergic Contact - etiology; Dyes; Female; Gold; gold sodium thiosulfate; Gold Sodium Thiosulfate - adverse effects; Humans; Japan; late reaction; Male; Middle Aged; Original; Oxidation; patch test; Patch Tests; Retrospective Studies; Sodium; Sodium thiosulfate; Thiosulfate; Time Factors; Young Adult; Japan; patch test; late reaction; active sensitization; gold sodium thiosulfate
• ISSN: 0105-1873; 1600-0536
• DOI: 10.1111/cod.13105

Background The proportion of positive test results with gold sodium thiosulfate included in a patch test panel (P‐GST) had been found to be greater than that with gold sodium thiosulfate 0.5% pet. by allergEAZE (A‐GST). Objectives To compare positive reactions to P‐GST and A‐GST, and to evaluate late reactions after the day (D) 7 reading. Methods A retrospective analysis was performed of 588 patients at participating departments (119 males; 469 females) who were patch tested with P‐GST and A‐GST in May 2015 to March 2016. Results Positive test reactions to P‐GST and A‐GST were observed in 15% and 6% of patients, respectively. Three patients reported a positive reaction occurring after the D7 reading. Conclusions Gold sodium thiosulfate often gives a positive reaction after 2 to 3 weeks, and, in such cases, the positive reaction may be sustained, so it is recommended to assess the reaction for up to 1 month after application.