Comparative analysis of immune cell subsets in peripheral blood from patients with periodontal disease and healthy controls

• Published in: Clinical and experimental immunology Vol. 194; no. 3; pp. 380 - 390
• Main Authors: Cheng, W.‐C., Saleh, F., Abuaisha Karim, B., Hughes, F. J., Taams, L. S.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2018; John Wiley and Sons Inc
• Subjects: Adult; Aggressive Periodontitis - immunology; Aggressive Periodontitis - pathology; Biofilms; Bone loss; CD14 antigen; CD19 antigen; CD25 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Chronic Periodontitis - immunology; Chronic Periodontitis - pathology; Colonization; Comparative analysis; Cytokines; Female; Flow cytometry; Gingiva - cytology; Gingiva - pathology; Gingivitis; Gingivitis - immunology; Gingivitis - pathology; Gum disease; Humans; Immunoregulation; Interferon; Interferon-gamma - blood; Interleukin-10 - blood; Interleukin-17 - blood; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Lymphocyte Subsets - immunology; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Middle Aged; Monocytes; Original; periodontal disease; Periodontitis; Peripheral blood mononuclear cells; Phenotypes; Serum levels; T helper 17 cells; Teeth; Tregs; Tumor necrosis factor; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumors; Young Adult; peripheral blood mononuclear cells; T helper 17 cells; Tregs; periodontal disease

Summary Periodontitis is a chronic inflammatory disease caused by the colonization of teeth by the bacterial plaque biofilm and the resultant host immune responses in adjacent periodontal tissues. Disease severity can vary dramatically between patients with periodontitis, with some subjects displayi...