Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy

• Published in: Clinical and experimental immunology Vol. 192; no. 2; pp. 151 - 164
• Main Authors: Kim, Y. S., Kim, M. N., Lee, K. E., Hong, J. Y., Oh, M. S., Kim, S. Y., Kim, K. W., Sohn, M. H.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2018; John Wiley and Sons Inc
• Subjects: activated leucocyte cell adhesion molecule; Activated-Leukocyte Cell Adhesion Molecule - blood; Activated-Leukocyte Cell Adhesion Molecule - genetics; Adoptive Transfer; ALCAM; Animal models; Animals; Antigen-presenting cells; Antigens, CD - genetics; Antigens, CD - immunology; Antigens, Differentiation, T-Lymphocyte - genetics; Antigens, Differentiation, T-Lymphocyte - immunology; CD166; CD3 antigen; CD4 antigen; CD6 antigen; Cell activation; Cell adhesion & migration; Cell adhesion molecules; Cell Proliferation; Child; Child, Preschool; Children; Coculture Techniques; Cytokines - genetics; Cytokines - immunology; Dendritic cells; Dendritic Cells - immunology; Disease Models, Animal; Female; Food allergies; food allergy; Food Hypersensitivity - immunology; Gene expression; Gene Expression Regulation - immunology; Humans; Immune response; Immunoglobulin E - blood; Immunoglobulins; Lymphocyte Activation; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Original; Ovalbumin; Public health; Rodents; Serum levels; T cell receptors; Th2 Cells - immunology; activated leucocyte cell adhesion molecule; ALCAM; food allergy; CD166

Summary Food allergy is a major public health problem. Studies have shown that long‐term interactions between activated leucocyte cell adhesion molecule (ALCAM/CD166) on the surface of antigen‐presenting cells, and CD6, a co‐stimulatory molecule, influence immune responses. However, there are curren...