Overactivation of the NF‐κB pathway impairs molar enamel formation

• Published in: Oral diseases Vol. 26; no. 7; pp. 1513 - 1522
• Main Authors: Yamada, Akane, Kawasaki, Maiko, Miake, Yasuo, Yamada, Yurie, Blackburn, James, Kawasaki, Katsushige, Trakanant, Supaluk, Nagai, Takahiro, Nihara, Jun, Kudo, Takehisa, Meguro, Fumiya, Schmidt‐Ullrich, Ruth, Liu, Bigang, Hu, Yinling, Page, Angustias, Ramírez, Ángel, Sharpe, Paul T., Maeda, Takeyasu, Takagi, Ritsuo, Ohazama, Atsushi
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.10.2020
• Subjects: Abrasion; Ameloblasts; Amelogenesis - genetics; Animals; Dental Enamel; Dysplasia; Ectoderm; Enamel; Humans; Keratin; Mice; Molar; Molars; NF-kappa B; NF‐κB; Teeth; tooth development; tooth development; NF-κB; enamel; molar

Objective Hypohidrotic ectodermal dysplasia (HED) is a hereditary disorder characterized by abnormal structures and functions of the ectoderm‐derived organs, including teeth. HED patients exhibit a variety of dental symptoms, such as hypodontia. Although disruption of the EDA/EDAR/EDARADD/NF‐κB path...