Stochastic parcel tracking in an Euler–Lagrange compartment model for fast simulation of fermentation processes

• Published in: Biotechnology and bioengineering Vol. 119; no. 7; pp. 1849 - 1860
• Main Authors: Haringa, Cees, Tang, Wenjun, Noorman, Henk J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2022; John Wiley and Sons Inc
• Subjects: Bioreactors; CFD; compartment model; Computational fluid dynamics; Computer applications; Computer Simulation; Euler–Lagrange; Fermentation; Flow profiles; Fluid dynamics; Hydrodynamics; Intracellular; Kinetics; Mathematical models; metabolic modeling; Microorganisms; Optimization; Penicillin; Simulation; Stochasticity; Tracking; CFD; Euler-Lagrange; fermentation; compartment model; metabolic modeling

The compartment model (CM) is a well‐known approach for computationally affordable, spatially resolved hydrodynamic modeling of unit operations. Recent implementations use flow profiles based on Computational Fluid Dynamics (CFD) simulations, and several authors included microbial kinetics to simula...