Longitudinal assessment of adhesion to vascular cell adhesion molecule‐1 at steady state and during vaso‐occlusive crises in sickle cell disease

• Published in: British journal of haematology Vol. 196; no. 4; pp. 1052 - 1058
• Main Authors: White, Jennell, Callaghan, Michael U., Gao, Xiufeng, Liu, Ke, Zaidi, Ahmar, Tarasev, Michael, Hines, Patrick C.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2022; John Wiley and Sons Inc
• Subjects: adhesion; Adhesives; Anemia, Sickle Cell - genetics; Case-Control Studies; Cell adhesion & migration; Cell adhesion molecules; Endothelium; Erythrocytes; Haemoglobinopathies; Hematology; Humans; Hydroxyurea; Longitudinal Studies; Phenotypes; Research Paper; Sickle cell anemia; Sickle cell disease; Vascular Cell Adhesion Molecule-1 - metabolism; vascular cell adhesion molecule‐1; vaso‐occlusion; very late antigen‐4; adhesion; vaso-occlusion; very late antigen-4; vascular cell adhesion molecule-1; sickle cell disease

Summary Sickle cell disease (SCD) is characterized by frequent and unpredictable vaso‐occlusive crises (VOCs). Sickle erythrocytes (SSRBCs) contribute to VOCs by participating in a series of adhesive events with blood cells and the vascular endothelium. Adhesion assays have been used to evaluate the...