Association of the polymorphism of the Toll‐like receptor (TLR)‐3 and TLR‐9 genes with hepatitis C virus‐specific cell‐mediated immunity outcomes among Egyptian health‐care workers

• Published in: Clinical and experimental immunology Vol. 203; no. 1; pp. 3 - 12
• Main Authors: Abdelwahab, S. F., Hamdy, S., Osman, A. M., Zakaria, Z. A., Galal, I., Sobhy, M., Hashem, M., Allam, W. R., Abdel‐Samiee, M., Rewisha, E., Waked, I.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2021; John Wiley and Sons Inc
• Subjects: Adult; cell‐mediated immunity; Chronic infection; CMI; CpG islands; Cytosine; Disease resistance; Double-stranded RNA; Editors' Choice; Enzyme-linked immunosorbent assay; Female; Gene polymorphism; Genomes; Genotype & phenotype; HCV; Health care; Health Personnel; health‐care workers; Hepacivirus - genetics; Hepacivirus - immunology; Hepatitis; Hepatitis C; Hepatitis C, Chronic - genetics; Hepatitis C, Chronic - immunology; Humans; Immune response; Immunity, Cellular; Infections; Interferon; Male; Middle Aged; Original; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Restriction fragment length polymorphism; Single-nucleotide polymorphism; SNP; Statistical analysis; TLR‐3; TLR‐9; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 3 - immunology; Toll-Like Receptor 9 - genetics; Toll-Like Receptor 9 - immunology; Toll-like receptors; health-care workers; TLR-3; SNP; TLR-9; HCV; CMI; cell-mediated immunity

We previously reported that TLR3.rs3775290 ‘CC’ genotype was associated with HCV chronicity, while TLR9 gene played no role in this infection. Herein, we show a significant association between the outcome of the HCV‐specific cell‐mediated immune (CMI) response and TLR9.rs5743836 genotype among the t...