Rejection of xenogeneic porcine islets in humanized mice is characterized by graft‐infiltrating Th17 cells and activated B cells

• Published in: American journal of transplantation Vol. 20; no. 6; pp. 1538 - 1550
• Main Authors: Lee, Frances T., Dangi, Anil, Shah, Sahil, Burnette, Melanie, Yang, Yong‐Guang, Kirk, Allan D., Hering, Bernhard J., Miller, Stephen D., Luo, Xunrong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.06.2020
• Subjects: Animals; B-Lymphocytes; basic (laboratory) research/science; Beta cells; CD4 antigen; CD44 antigen; CD45 antigen; Diabetes mellitus (insulin dependent); Graft rejection; Graft Rejection - prevention & control; Graft Survival; Helper cells; Immune response; Immunomodulation; Immunomodulators; immunosuppression/immune modulation; Immunotherapy; Infiltration; Islet cells; islet transplantation; Islets of Langerhans Transplantation; Lymphocytes T; Macrophages; Mice; Monoclonal antibodies; Pancreatic islet transplantation; Rapamycin; rejection; Rituximab; Splenocytes; Swine; Th17 Cells; tolerance; Transplantation, Heterologous; Transplants & implants; xenoantigen; Xenografts; xenotransplantation; immunosuppression/immune modulation; islet transplantation; xenotransplantation; xenoantigen; rejection; tolerance; basic (laboratory) research/science

Xenogeneic porcine islet transplantation is a promising potential therapy for type 1 diabetes (T1D). Understanding human immune responses against porcine islets is crucial for the design of optimal immunomodulatory regimens for effective control of xenogeneic rejection of porcine islets in humans. H...