Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS)

• Published in: Diabetic medicine Vol. 34; no. 12; pp. 1747 - 1755
• Main Authors: Perreault, L., Pan, Q., Aroda, V. R., Barrett‐Connor, E., Dabelea, D., Dagogo‐Jack, S., Hamman, R. F., Kahn, S. E., Mather, K. J., Knowler, W. C.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2017
• Subjects: Adult; Antihypertensives; Blood pressure; Demography; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - prevention & control; Diabetic Angiopathies - epidemiology; Diabetic Angiopathies - prevention & control; Diet, Reducing; Disease prevention; Exercise Therapy; Female; Follow-Up Studies; Humans; Hypertension; Male; Metformin - therapeutic use; Microvasculature; Middle Aged; Obesity - complications; Obesity - epidemiology; Obesity - therapy; Overweight - complications; Overweight - epidemiology; Overweight - therapy; Prediabetic State - complications; Prediabetic State - epidemiology; Prediabetic State - pathology; Prediabetic State - therapy; Prevalence; Risk Factors; Risk groups; Risk Reduction Behavior; Treatment Outcome; Weight Reduction Programs - methods

Aim Approximately half of the participants in the Diabetes Prevention Outcomes Study (DPPOS) had diabetes after 15 years of follow‐up, whereas nearly all the others remained with pre‐diabetes. We examined whether formerly unexplored factors in the DPPOS coexisted with known risk factors that posed a...