Hypoxic regulation of angiotensin‐converting enzyme 2 and Mas receptor in human CD34+ cells

• Published in: Journal of cellular physiology Vol. 234; no. 11; pp. 20420 - 20431
• Main Authors: Joshi, Shrinidh, Wollenzien, Hannah, Leclerc, Estelle, Jarajapu, Yagna PR
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2019
• Subjects: ACE2; Adult; Aged; Angiotensin AT1 receptors; Angiotensin-Converting Enzyme 2; Antigens, CD34 - immunology; CD34 antigen; CD34+ cells; Cell migration; Cell proliferation; Cells (biology); Enzymes; Female; Growth factors; Hematopoietic stem cells; Humans; Hypoxia; Hypoxia - metabolism; Ischemia; Leukocytes (mononuclear); Male; Mas receptor; Middle Aged; Peptide Fragments - metabolism; Peptidyl-Dipeptidase A - metabolism; Plasmids; Progenitor cells; Proto-Oncogene Mas; Proto-Oncogene Proteins - metabolism; Receptors, G-Protein-Coupled - metabolism; Renin-Angiotensin System - physiology; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; ACE2; hypoxia; Mas receptor; CD34+ cells

CD34+ hematopoietic stem/progenitor cells (HSPCs) are vasculogenic and hypoxia is a strong stimulus for the vasoreparative functions of these cells. Angiotensin‐converting enzyme 2 (ACE2)/angiotensin‐(1–7)/Mas receptor (MasR) pathway stimulates vasoprotective functions of CD34+ cells. This study tes...