Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease

• Published in: American journal of hematology Vol. 95; no. 11; pp. 1246 - 1256
• Main Authors: Kucukal, Erdem, Man, Yuncheng, Hill, Ailis, Liu, Shichen, Bode, Allison, An, Ran, Kadambi, Jaikrishnan, Little, Jane A., Gurkan, Umut A.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2020; Wiley Subscription Services, Inc
• Subjects: Anemia, Sickle Cell - blood; Biomarkers; Biomarkers - blood; Blood; Blood Viscosity; Cell Adhesion; Cell adhesion & migration; Erythrocytes; Erythrocytes, Abnormal - metabolism; Female; Hematocrit; Hematology; Hemoglobin; Hereditary diseases; Humans; Hypoxia; Laminin; Male; Microfluidics; Point mutation; Rheology; Sickle cell disease

Sickle cell disease (SCD) is a recessive genetic blood disorder exhibiting abnormal blood rheology. Polymerization of sickle hemoglobin, due to a point mutation in the β‐globin gene of hemoglobin, results in aberrantly adhesive and stiff red blood cells (RBCs). Hemolysis, abnormal RBC adhesion, and...