α‐Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α‐Synuclein in the Context of Co‐Pathology and Non‐LBD Diagnoses

• Published in: Annals of neurology Vol. 92; no. 4; pp. 650 - 662
• Main Authors: Arnold, Moriah R., Coughlin, David G., Brumbach, Barbara H., Smirnov, Denis S., Concha‐Marambio, Luis, Farris, Carly M., Ma, Yihua, Kim, Yongya, Wilson, Edward N., Kaye, Jeffrey A., Hiniker, Annie, Woltjer, Randy L., Galasko, Doug R., Quinn, Joseph F.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2022; Wiley Subscription Services, Inc
• Subjects: alpha-Synuclein - metabolism; Amplification; Amygdala; Autopsies; Autopsy; Brain; Brain - pathology; Cerebrospinal fluid; Cortex (frontal); Differential diagnosis; Humans; Lewy bodies; Lewy body disease; Pathology; Patients; Seeds; Sensitivity; Sensitivity and Specificity; Synuclein; Tissue analysis

Objective The purpose of this study was to determine the sensitivity and specificity of α‐synuclein seed amplification assay (αSyn‐SAA) in antemortem and postmortem cerebrospinal fluid (CSF) of autopsy‐confirmed patients with different distributions of pathological αSyn, co‐pathologies, and clinical...