Influence of the phosphoenolpyruvate:carbohydrate phosphotransferase system on toxin gene expression and virulence in Bacillus anthracis

• Published in: Molecular microbiology Vol. 113; no. 1; pp. 237 - 252
• Main Authors: Bier, Naomi, Hammerstrom, Troy G., Koehler, Theresa M.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2020
• Subjects: Anthrax; Bacillus anthracis; Carbohydrates; Crystal structure; Enzyme I; Gene expression; Phosphorylation; Phosphotransferase; Proteins; Regulators; Toxins; Transcription; Virulence

Summary AtxA, the master virulence gene regulator of Bacillus anthracis, is a PRD‐Containing Virulence Regulator (PCVR) as indicated by the crystal structure, post‐translational modifications and activity of the protein. PCVRs are transcriptional regulators, named for PTS Regulatory Domains (PRDs) s...