The Effects of Long‐term Administration of rhPTH(1‐84) in Hypoparathyroidism by Bone Histomorphometry
ABSTRACT Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1‐84) [rhPTH(1‐84)] in short‐term studies has beneficial skeletal effects. Although rhPTH(1‐84) will likely be used indefinitely, long‐term effects on skeletal micr...
Saved in:
| Published in | Journal of bone and mineral research Vol. 33; no. 11; pp. 1931 - 1939 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
01.11.2018
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | ABSTRACT
Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1‐84) [rhPTH(1‐84)] in short‐term studies has beneficial skeletal effects. Although rhPTH(1‐84) will likely be used indefinitely, long‐term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3 ± 1 years of rhPTH(1‐84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1‐84), skeletal remodeling indices were markedly suppressed. With long‐term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26‐fold (0.3 ± 1 to 7.9 ± 7%, p = 0.003), bone formation rate increased by 15‐fold (0.003 ± 0.01 to 0.047 ± 0.05 μm2/μm/day, p = 0.007), osteoid width doubled (1.9 ± 1 to 4.3 ± 1 lamellae, p = 0.017), and osteoid surface tripled (3.3 ± 3 to 10.8 ± 6%, p = 0.011). Bone resorption as measured by eroded surface increased (4.6 ± 2 to 7.5 ± 3%, p = 0.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6 ± 5 to 29.1 ± 11%, p = 0.017) and trabecular number (1.8 ± 1 to 2.5 ± 1 #/mm, p = 0.025). Cortical porosity tended to increase (6.3 ± 5 to 9.5 ± 3%, p = 0.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. © 2018 American Society for Bone and Mineral Research. |
|---|---|
| AbstractList | Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1–84) [rhPTH(1–84)] in short-term studies has beneficial skeletal effects. Although rhPTH(1–84) will likely be used indefinitely, long-term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3±1 years of rhPTH(1–84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1–84), skeletal remodeling indices were markedly suppressed. With long-term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26-fold (0.3±1 to 7.9±7%,
p
=0.003), bone formation rate increased by 15-fold (0.003±0.01 to 0.047±0.05 µm
2
/µm/day,
p
=0.007), osteoid width doubled (1.9±1 to 4.3±1 lamellae,
p
=0.017), and osteoid surface tripled (3.3±3 to 10.8±6%,
p
=0.011). Bone resorption as measured by eroded surface increased (4.6±2 to 7.5±3%,
p
=0.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6±5 to 29.1±11%,
p
=0.017) and trabecular number (1.8±1 to 2.5±1 #/mm,
p
=0.025). Cortical porosity tended to increase (6.3±5 to 9.5±3%,
p
=0.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. ABSTRACT Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1‐84) [rhPTH(1‐84)] in short‐term studies has beneficial skeletal effects. Although rhPTH(1‐84) will likely be used indefinitely, long‐term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3 ± 1 years of rhPTH(1‐84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1‐84), skeletal remodeling indices were markedly suppressed. With long‐term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26‐fold (0.3 ± 1 to 7.9 ± 7%, p = 0.003), bone formation rate increased by 15‐fold (0.003 ± 0.01 to 0.047 ± 0.05 μm2/μm/day, p = 0.007), osteoid width doubled (1.9 ± 1 to 4.3 ± 1 lamellae, p = 0.017), and osteoid surface tripled (3.3 ± 3 to 10.8 ± 6%, p = 0.011). Bone resorption as measured by eroded surface increased (4.6 ± 2 to 7.5 ± 3%, p = 0.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6 ± 5 to 29.1 ± 11%, p = 0.017) and trabecular number (1.8 ± 1 to 2.5 ± 1 #/mm, p = 0.025). Cortical porosity tended to increase (6.3 ± 5 to 9.5 ± 3%, p = 0.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. © 2018 American Society for Bone and Mineral Research. Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] in short-term studies has beneficial skeletal effects. Although rhPTH(1-84) will likely be used indefinitely, long-term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3 ± 1 years of rhPTH(1-84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1-84), skeletal remodeling indices were markedly suppressed. With long-term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26-fold (0.3 ± 1 to 7.9 ± 7%, p = 0.003), bone formation rate increased by 15-fold (0.003 ± 0.01 to 0.047 ± 0.05 μm /μm/day, p = 0.007), osteoid width doubled (1.9 ± 1 to 4.3 ± 1 lamellae, p = 0.017), and osteoid surface tripled (3.3 ± 3 to 10.8 ± 6%, p = 0.011). Bone resorption as measured by eroded surface increased (4.6 ± 2 to 7.5 ± 3%, p = 0.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6 ± 5 to 29.1 ± 11%, p = 0.017) and trabecular number (1.8 ± 1 to 2.5 ± 1 #/mm, p = 0.025). Cortical porosity tended to increase (6.3 ± 5 to 9.5 ± 3%, p = 0.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. © 2018 American Society for Bone and Mineral Research. Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1‐84) [rhPTH(1‐84)] in short‐term studies has beneficial skeletal effects. Although rhPTH(1‐84) will likely be used indefinitely, long‐term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3 ± 1 years of rhPTH(1‐84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1‐84), skeletal remodeling indices were markedly suppressed. With long‐term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26‐fold (0.3 ± 1 to 7.9 ± 7%, p = 0.003), bone formation rate increased by 15‐fold (0.003 ± 0.01 to 0.047 ± 0.05 μm2/μm/day, p = 0.007), osteoid width doubled (1.9 ± 1 to 4.3 ± 1 lamellae, p = 0.017), and osteoid surface tripled (3.3 ± 3 to 10.8 ± 6%, p = 0.011). Bone resorption as measured by eroded surface increased (4.6 ± 2 to 7.5 ± 3%, p = 0.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6 ± 5 to 29.1 ± 11%, p = 0.017) and trabecular number (1.8 ± 1 to 2.5 ± 1 #/mm, p = 0.025). Cortical porosity tended to increase (6.3 ± 5 to 9.5 ± 3%, p = 0.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. © 2018 American Society for Bone and Mineral Research. Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] in short-term studies has beneficial skeletal effects. Although rhPTH(1-84) will likely be used indefinitely, long-term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3 ± 1 years of rhPTH(1-84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1-84), skeletal remodeling indices were markedly suppressed. With long-term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26-fold (0.3 ± 1 to 7.9 ± 7%, p = 0.003), bone formation rate increased by 15-fold (0.003 ± 0.01 to 0.047 ± 0.05 μm2 /μm/day, p = 0.007), osteoid width doubled (1.9 ± 1 to 4.3 ± 1 lamellae, p = 0.017), and osteoid surface tripled (3.3 ± 3 to 10.8 ± 6%, p = 0.011). Bone resorption as measured by eroded surface increased (4.6 ± 2 to 7.5 ± 3%, p = 0.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6 ± 5 to 29.1 ± 11%, p = 0.017) and trabecular number (1.8 ± 1 to 2.5 ± 1 #/mm, p = 0.025). Cortical porosity tended to increase (6.3 ± 5 to 9.5 ± 3%, p = 0.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. © 2018 American Society for Bone and Mineral Research.Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] in short-term studies has beneficial skeletal effects. Although rhPTH(1-84) will likely be used indefinitely, long-term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3 ± 1 years of rhPTH(1-84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1-84), skeletal remodeling indices were markedly suppressed. With long-term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26-fold (0.3 ± 1 to 7.9 ± 7%, p = 0.003), bone formation rate increased by 15-fold (0.003 ± 0.01 to 0.047 ± 0.05 μm2 /μm/day, p = 0.007), osteoid width doubled (1.9 ± 1 to 4.3 ± 1 lamellae, p = 0.017), and osteoid surface tripled (3.3 ± 3 to 10.8 ± 6%, p = 0.011). Bone resorption as measured by eroded surface increased (4.6 ± 2 to 7.5 ± 3%, p = 0.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6 ± 5 to 29.1 ± 11%, p = 0.017) and trabecular number (1.8 ± 1 to 2.5 ± 1 #/mm, p = 0.025). Cortical porosity tended to increase (6.3 ± 5 to 9.5 ± 3%, p = 0.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. © 2018 American Society for Bone and Mineral Research. |
| Author | Rubin, Mishaela R Majeed, Rukshana Zhou, Hua Bilezikian, John P Dempster, David W Gomez, Maximo Omeragic, Beatriz Cusano, Natalie E Nickolas, Thomas L |
| AuthorAffiliation | 3 Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, NY, USA 2 Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York, USA 1 Department of Medicine, Metabolic Bone Diseases Unit, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, New York, NY, USA |
| AuthorAffiliation_xml | – name: 2 Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York, USA – name: 3 Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, NY, USA – name: 1 Department of Medicine, Metabolic Bone Diseases Unit, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, New York, NY, USA |
| Author_xml | – sequence: 1 givenname: Mishaela R surname: Rubin fullname: Rubin, Mishaela R email: mrr6@columbia.edu organization: Columbia University – sequence: 2 givenname: Hua surname: Zhou fullname: Zhou, Hua organization: Helen Hayes Hospital – sequence: 3 givenname: Natalie E surname: Cusano fullname: Cusano, Natalie E organization: Columbia University – sequence: 4 givenname: Rukshana surname: Majeed fullname: Majeed, Rukshana organization: Columbia University – sequence: 5 givenname: Beatriz surname: Omeragic fullname: Omeragic, Beatriz organization: Columbia University – sequence: 6 givenname: Maximo surname: Gomez fullname: Gomez, Maximo organization: Columbia University – sequence: 7 givenname: Thomas L surname: Nickolas fullname: Nickolas, Thomas L organization: Columbia University – sequence: 8 givenname: David W surname: Dempster fullname: Dempster, David W organization: Columbia University – sequence: 9 givenname: John P surname: Bilezikian fullname: Bilezikian, John P organization: Columbia University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29972871$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1u1DAUhS1URKcDC14ARWLTLtL6L06yQWqrlgENAqFhbXmSm8aj2A52hiq7PkKfsU9Sp50iqGBh2dL9ztG5PgdozzoLCL0l-JhgTE82a-OPWcbZCzQjGWUpFwXZQzNcFDzFnJF9dBDCBmMsMiFeoX1aljktcjJDetVCctE0UA0hcU2ydPbq7uZ2AG-S09poq8Pg1aCdnaa-_bZaHJIIFPwo0TZZjL3rVQTa0Ttd62CS9ZicxXjJIiqdcb5vnYHBj6_Ry0Z1Ad7s7jn6cXmxOl-ky68fP52fLtOKc8ZSQUleANQ1EEKZKkQGwEQtcpoTUYp6rRQIVdN4KgxZoaAklMYnZEw1ecXm6MOjb79dG6grsHGBTvZeG-VH6ZSWf0-sbuWV-yVFxgUti2hwuDPw7ucWwiCNDhV0nbLgtkFSLHie85JP6Ptn6MZtvY3rSUpomTFOYitz9O7PRL-jPLUQgZNHoPIuBA-NrPTw8OkxoO4kwXLqWU49y6nnqDh6pngy_Re7c7_WHYz_B-Xnsy_fHxT3hES60w |
| CitedBy_id | crossref_primary_10_4103_ijem_IJEM_579_19 crossref_primary_10_1002_jbm4_10829 crossref_primary_10_1007_s11914_023_00790_x crossref_primary_10_1007_s11154_020_09614_0 crossref_primary_10_23736_S2724_6507_21_03527_2 crossref_primary_10_1007_s40618_020_01269_7 crossref_primary_10_12688_f1000research_22717_1 crossref_primary_10_1097_BOR_0000000000000618 crossref_primary_10_1007_s00784_019_03068_8 crossref_primary_10_1007_s40618_022_01818_2 crossref_primary_10_3390_polym13111797 crossref_primary_10_1056_NEJMcp1800213 crossref_primary_10_1002_jbmr_4005 crossref_primary_10_1210_clinem_dgaa113 crossref_primary_10_1210_jc_2019_00893 crossref_primary_10_1016_j_bone_2018_11_012 crossref_primary_10_1093_jbmrpl_ziae045 crossref_primary_10_1210_endrev_bnab005 crossref_primary_10_3390_polym12051201 crossref_primary_10_1210_jc_2019_01010 crossref_primary_10_1002_jbmr_4780 crossref_primary_10_1007_s00198_019_05177_2 |
| Cites_doi | 10.1007/s10735-007-9096-3 10.1002/jbmr.1493 10.1359/jbmr.2003.18.11.1932 10.1002/jbmr.2609 10.1016/8756-3282(92)90203-9 10.1002/jbmr.2273 10.1002/jbmr.483 10.1002/jbmr.5650030203 10.1007/s00198-009-1168-7 10.1007/s00198-014-2814-2 10.1359/jbmr.090527 10.1359/jbmr.080803 10.1002/jbmr.2588 10.1016/j.bone.2014.07.014 10.1210/jc.2011-0566 10.1002/jbmr.1627 10.1210/jc.2012-1808 10.1359/jbmr.1997.12.6.948 10.1002/jbmr.1805 10.1016/j.bone.2009.09.020 10.1002/jbmr.2501 10.1002/jbmr.1979 10.1007/s00198-009-1149-x 10.1016/j.bone.2008.09.019 10.1016/8756-3282(95)00443-2 10.1210/jc.2004-2489 10.1016/j.bone.2013.11.011 10.1016/S0140-6736(97)02342-8 10.1056/NEJMcp0803050 10.1359/jbmr.081233 10.1007/BF00441552 10.1172/JCI113690 10.1002/jbmr.452 10.1210/jc.2015-4135 |
| ContentType | Journal Article |
| Copyright | 2018 American Society for Bone and Mineral Research 2018 American Society for Bone and Mineral Research. |
| Copyright_xml | – notice: 2018 American Society for Bone and Mineral Research – notice: 2018 American Society for Bone and Mineral Research. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP 7TS K9. 7X8 5PM |
| DOI | 10.1002/jbmr.3543 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Physical Education Index ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Calcium & Calcified Tissue Abstracts Physical Education Index MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1523-4681 |
| EndPage | 1939 |
| ExternalDocumentID | PMC6546298 29972871 10_1002_jbmr_3543 JBMR3543 |
| Genre | article Clinical Trial Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIH funderid: R01 DK069350; DK32333; K23DK067619; R01 FD002525 – fundername: NPS/Shire Pharmaceuticals – fundername: NIDDK NIH HHS grantid: K23 DK067619 – fundername: NIDDK NIH HHS grantid: R01 DK069350 – fundername: FDA HHS grantid: R01 FD002525 – fundername: NIDDK NIH HHS grantid: R01 DK032333 |
| GroupedDBID | --- .55 .GJ 05W 0R~ 1OB 1OC 24P 29K 2WC 31~ 33P 3SF 3WU 4.4 50Y 52U 53G 5GY 5RE 5WD 66C 8-0 8-1 A00 AAESR AAEVG AAHHS AANHP AANLZ AAONW AASGY AAUAY AAXRX AAYCA AAZKR ABCUV ABDFA ABEFU ABEJV ABJNI ABNHQ ABQNK ABXGK ABXVV ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACXBN ACXQS ACYXJ ACZBC ADBTR ADEOM ADIPN ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFGKR AFPWT AFWVQ AFZJQ AGMDO AHMBA AHMMS AIACR AIURR AIWBW AJAOE AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVNTJ AVWKF AZBYB AZFZN AZVAB BCRHZ BDRZF BFHJK BHBCM BMXJE BNHUX BOGZA BQCPF BRXPI CS3 D-I DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD EMOBN F5P FEDTE FUBAC G-S GK1 GODZA HVGLF HZ~ IJI IX1 KBYEO LATKE LEEKS LITHE LOXES LUTES LYRES MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM MY~ NNB O66 O9- OCZFY OJZSN OK1 OVD OWPYF P2P P2W P4E PALCI PQQKQ R.K RIG RIWAO RJQFR ROL ROX RWI RX1 SJN SUPJJ TEORI TR2 VJK W99 WBKPD WIH WIJ WIK WNSPC WOHZO WYISQ WYJ X7M XV2 ZGI ZXP ZZTAW ~S- AAYXX ABGNP AGORE AJNCP CITATION KOP ACVCV AFFQV AJDVS CGR CUY CVF ECM EIF NPM 7QP 7TS AAMMB AEFGJ AGXDD AIDQK AIDYY K9. 7X8 5PM WIN |
| ID | FETCH-LOGICAL-c4433-62178eedde1123a865ee36d67271696dbaae6ad26adc0e58ae9122c0ee53af7c3 |
| IEDL.DBID | DR2 |
| ISSN | 0884-0431 1523-4681 |
| IngestDate | Thu Aug 21 18:16:06 EDT 2025 Fri Jul 11 02:44:51 EDT 2025 Fri Jul 25 21:22:39 EDT 2025 Thu Apr 03 07:05:07 EDT 2025 Thu Apr 24 22:56:58 EDT 2025 Tue Jul 01 04:13:10 EDT 2025 Wed Jan 22 16:38:00 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | CORTICAL POROSITY TRABECULAR TUNNELING HISTOMORPHOMETRY HYPOPARATHYROIDISM RHPTH(1-84) |
| Language | English |
| License | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model 2018 American Society for Bone and Mineral Research. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4433-62178eedde1123a865ee36d67271696dbaae6ad26adc0e58ae9122c0ee53af7c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://asbmr.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.3543 |
| PMID | 29972871 |
| PQID | 2129534154 |
| PQPubID | 1006376 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6546298 proquest_miscellaneous_2064774948 proquest_journals_2129534154 pubmed_primary_29972871 crossref_citationtrail_10_1002_jbmr_3543 crossref_primary_10_1002_jbmr_3543 wiley_primary_10_1002_jbmr_3543_JBMR3543 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | November 2018 |
| PublicationDateYYYYMMDD | 2018-11-01 |
| PublicationDate_xml | – month: 11 year: 2018 text: November 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Baltimore |
| PublicationTitle | Journal of bone and mineral research |
| PublicationTitleAlternate | J Bone Miner Res |
| PublicationYear | 2018 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| References | 2009; 44 2009; 24 1996; 18 2013; 28 1997; 350 2005; 90 2015; 30 2016; 101 2016; 31 2011; 96 2014; 25 1992; 13 2003; 18 1999; 84 2014; 29 2014; 67 2012; 97 2007; 38 2010; 21 1988; 3 2010; 46 1989; 148 1997; 12 2014; 59 2008; 23 2008; 359 2011; 26 2012; 27 1996; 81 1988; 82 Mitchell (2024021014284297600_jbmr3543-bib-0008) 2012; 97 Silvestrini (2024021014284297600_jbmr3543-bib-0030) 2007; 38 Underbjerg (2024021014284297600_jbmr3543-bib-0022) 2015; 30 Mizunashi (2024021014284297600_jbmr3543-bib-0005) 1988; 82 Hofstetter (2024021014284297600_jbmr3543-bib-0035) 2014; 25 Rubin (2024021014284297600_jbmr3543-bib-0018) 2010; 46 Eriksen (2024021014284297600_jbmr3543-bib-0032) 2014; 67 Cusano (2024021014284297600_jbmr3543-bib-0020) 2016; 31 Stepan (2024021014284297600_jbmr3543-bib-0026) 2010; 21 Recker (2024021014284297600_jbmr3543-bib-0011) 1988; 3 Lindsay (2024021014284297600_jbmr3543-bib-0029) 1997; 350 Sikjaer (2024021014284297600_jbmr3543-bib-0019) 2012; 27 Dobnig (2024021014284297600_jbmr3543-bib-0033) 2009; 24 Paschalis (2024021014284297600_jbmr3543-bib-0034) 2005; 90 Kruse (2024021014284297600_jbmr3543-bib-0004) 1989; 148 Underbjerg (2024021014284297600_jbmr3543-bib-0023) 2013; 28 Misof (2024021014284297600_jbmr3543-bib-0036) 2016; 31 Underbjerg (2024021014284297600_jbmr3543-bib-0021) 2014; 29 Parisien (2024021014284297600_jbmr3543-bib-0012) 1997; 12 Recker (2024021014284297600_jbmr3543-bib-0028) 2009; 44 Dempster (2024021014284297600_jbmr3543-bib-0016) 1999; 84 Dempster (2024021014284297600_jbmr3543-bib-0017) 2013; 28 Jiang (2024021014284297600_jbmr3543-bib-0025) 2003; 18 2024021014284297600_jbmr3543-bib-0009 Rubin (2024021014284297600_jbmr3543-bib-0014) 2010; 21 Rubin (2024021014284297600_jbmr3543-bib-0015) 2016; 101 Langdahl (2024021014284297600_jbmr3543-bib-0003) 1996; 18 Cosman (2024021014284297600_jbmr3543-bib-0024) 1992; 13 Theman (2024021014284297600_jbmr3543-bib-0037) 2009; 24 Ma (2024021014284297600_jbmr3543-bib-0027) 2014; 59 Rubin (2024021014284297600_jbmr3543-bib-0002) 2008; 23 Shoback (2024021014284297600_jbmr3543-bib-0001) 2008; 359 Gafni (2024021014284297600_jbmr3543-bib-0010) 2012; 27 Bilezikian (2024021014284297600_jbmr3543-bib-0007) 2011; 26 Costa (2024021014284297600_jbmr3543-bib-0031) 2011; 96 Rubin (2024021014284297600_jbmr3543-bib-0006) 2011; 26 Clarke (2024021014284297600_jbmr3543-bib-0013) 1996; 81 |
| References_xml | – volume: 27 start-page: 781 issue: 4 year: 2012 end-page: 8 article-title: Changes in 3‐dimensional bone structure indices in hypoparathyroid patients treated with PTH(1‐84): a randomized controlled study publication-title: J Bone Miner Res – volume: 31 start-page: 308 issue: 2 year: 2016 end-page: 316 article-title: Noninvasive assessment of skeletal microstructure and estimated bone strength in hypoparathyroidism publication-title: J Bone Miner Res – volume: 81 start-page: 2264 issue: 6 year: 1996 end-page: 70 article-title: Changes in quantitative bone histomorphometry in aging healthy men publication-title: J Clin Endocrinol Metab – volume: 350 start-page: 550 issue: 9077 year: 1997 end-page: 5 article-title: Randomised controlled study of effect of parathyroid hormone on vertebral‐bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis publication-title: Lancet – volume: 96 start-page: 3804 issue: 12 year: 2011 end-page: 10 article-title: Circulating sclerostin in disorders of parathyroid gland function publication-title: J Clin Endocrinol Metab – volume: 44 start-page: 113 issue: 1 year: 2009 end-page: 9 article-title: Cancellous and cortical bone architecture and turnover at the iliac crest of postmenopausal osteoporotic women treated with parathyroid hormone 1‐84 publication-title: Bone – volume: 29 start-page: 2504 issue: 11 year: 2014 end-page: 10 article-title: Postsurgical hypoparathyroidism—risk of fractures, psychiatric diseases, cancer, cataract, and infections publication-title: J Bone Miner Res – volume: 18 start-page: 1932 issue: 11 year: 2003 end-page: 41 article-title: Recombinant human parathyroid hormone (1‐34) [teriparatide] improves both cortical and cancellous bone structure publication-title: J Bone Miner Res – volume: 24 start-page: 964 issue: 5 year: 2009 end-page: 73 article-title: PTH(1‐34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation publication-title: J Bone Miner Res – volume: 12 start-page: 948 issue: 6 year: 1997 end-page: 57 article-title: Histomorphometric assessment of bone mass, structure, and remodeling: a comparison between healthy black and white premenopausal women publication-title: J Bone Miner Res – volume: 21 start-page: 1927 issue: 11 year: 2010 end-page: 34 article-title: Therapy of hypoparathyroidism with intact parathyroid hormone publication-title: Osteoporos Int – volume: 13 start-page: 237 issue: 3 year: 1992 end-page: 42 article-title: Relationships between quantitative histological measurements and noninvasive assessments of bone mass publication-title: Bone – volume: 23 start-page: 2018 issue: 12 year: 2008 end-page: 24 article-title: Dynamic and structural properties of the skeleton in hypoparathyroidism publication-title: J Bone Miner Res – volume: 28 start-page: 2277 issue: 11 year: 2013 end-page: 85 article-title: Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow‐up study publication-title: J Bone Miner Res – volume: 25 start-page: 2709 issue: 12 year: 2014 end-page: 19 article-title: Bone quality of the newest bone formed after two years of teriparatide therapy in patients who were previously treatment‐naive or on long‐term alendronate therapy publication-title: Osteoporos Int – volume: 18 start-page: 103 issue: 2 year: 1996 end-page: 8 article-title: Bone histomorphometry in hypoparathyroid patients treated with vitamin D publication-title: Bone – volume: 27 start-page: 1811 issue: 8 year: 2012 end-page: 20 article-title: Daily parathyroid hormone 1‐34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure publication-title: J Bone Miner Res – volume: 26 start-page: 2317 issue: 10 year: 2011 end-page: 37 article-title: Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target‐organ involvement, treatment, and challenges for future research publication-title: J Bone Miner Res – volume: 30 start-page: 1738 issue: 9 year: 2015 end-page: 44 article-title: The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study publication-title: J Bone Miner Res – volume: 38 start-page: 261 issue: 4 year: 2007 end-page: 9 article-title: Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone publication-title: J Mol Histol – volume: 359 start-page: 391 issue: 4 year: 2008 end-page: 403 article-title: Clinical practice. Hypoparathyroidism publication-title: N Engl J Med – volume: 24 start-page: 1998 issue: 12 year: 2009 end-page: 2006 article-title: Teriparatide reduces bone microdamage accumulation in postmenopausal women previously treated with alendronate publication-title: J Bone Miner Res – volume: 148 start-page: 535 issue: 6 year: 1989 end-page: 9 article-title: Biochemical markers of bone turnover, intact serum parathyroid horn and renal calcium excretion in patients with pseudohypoparathyroidism and hypoparathyroidism before and during vitamin D treatment publication-title: Eur J Pediatr – volume: 97 start-page: 4507 issue: 12 year: 2012 end-page: 14 article-title: Long‐term follow‐up of patients with hypoparathyroidism publication-title: J Clin Endocrinol Metab – volume: 46 start-page: 190 issue: 1 year: 2010 end-page: 5 article-title: Three dimensional cancellous bone structure in hypoparathyroidism publication-title: Bone – volume: 59 start-page: 139 year: 2014 end-page: 47 article-title: Effects of teriparatide on cortical histomorphometric variables in postmenopausal women with or without prior alendronate treatment publication-title: Bone – volume: 26 start-page: 2727 issue: 11 year: 2011 end-page: 36 article-title: PTH(1‐84) administration reverses abnormal bone‐remodeling dynamics and structure in hypoparathyroidism publication-title: J Bone Miner Res – volume: 3 start-page: 133 issue: 2 year: 1988 end-page: 44 article-title: Static and tetracycline‐based bone histomorphometric data from 34 normal postmenopausal females publication-title: J Bone Miner Res – volume: 67 start-page: 246 year: 2014 end-page: 56 article-title: Literature review: the effects of teriparatide therapy at the hip in patients with osteoporosis publication-title: Bone – volume: 82 start-page: 861 issue: 3 year: 1988 end-page: 5 article-title: Effects of active vitamin D3 and parathyroid hormone on the serum osteocalcin in idiopathic hypoparathyroidism and pseudohypoparathyroidism publication-title: J Clin Invest – volume: 101 start-page: 2742 issue: 7 year: 2016 end-page: 50 article-title: Therapy of hypoparathyroidism with PTH(1‐84): a prospective six year investigation of efficacy and safety publication-title: J Clin Endocrinol Metab – volume: 84 start-page: 1562 issue: 5 year: 1999 end-page: 6 article-title: On the mechanism of cancellous bone preservation in postmenopausal women with mild primary hyperparathyroidism publication-title: J Clin Endocrinol Metab – volume: 90 start-page: 4644 issue: 8 year: 2005 end-page: 9 article-title: Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trial publication-title: J Clin Endocrin Metabol – volume: 28 start-page: 2 issue: 1 year: 2013 end-page: 17 article-title: Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee publication-title: J Bone Miner Res – volume: 21 start-page: 2027 issue: 12 year: 2010 end-page: 36 article-title: Histomorphometric changes by teriparatide in alendronate‐pretreated women with osteoporosis publication-title: Osteoporos Int – volume: 31 start-page: 180 issue: 1 year: 2016 end-page: 9 article-title: PTH(1‐84) Administration in hypoparathyroidism transiently reduces bone matrix mineralization publication-title: J Bone Miner Res – volume: 81 start-page: 2264 issue: 6 year: 1996 ident: 2024021014284297600_jbmr3543-bib-0013 article-title: Changes in quantitative bone histomorphometry in aging healthy men publication-title: J Clin Endocrinol Metab – volume: 38 start-page: 261 issue: 4 year: 2007 ident: 2024021014284297600_jbmr3543-bib-0030 article-title: Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone publication-title: J Mol Histol doi: 10.1007/s10735-007-9096-3 – volume: 27 start-page: 781 issue: 4 year: 2012 ident: 2024021014284297600_jbmr3543-bib-0019 article-title: Changes in 3-dimensional bone structure indices in hypoparathyroid patients treated with PTH(1-84): a randomized controlled study publication-title: J Bone Miner Res doi: 10.1002/jbmr.1493 – volume: 84 start-page: 1562 issue: 5 year: 1999 ident: 2024021014284297600_jbmr3543-bib-0016 article-title: On the mechanism of cancellous bone preservation in postmenopausal women with mild primary hyperparathyroidism publication-title: J Clin Endocrinol Metab – volume: 18 start-page: 1932 issue: 11 year: 2003 ident: 2024021014284297600_jbmr3543-bib-0025 article-title: Recombinant human parathyroid hormone (1-34) [teriparatide] improves both cortical and cancellous bone structure publication-title: J Bone Miner Res doi: 10.1359/jbmr.2003.18.11.1932 – volume: 31 start-page: 308 issue: 2 year: 2016 ident: 2024021014284297600_jbmr3543-bib-0020 article-title: Noninvasive assessment of skeletal microstructure and estimated bone strength in hypoparathyroidism publication-title: J Bone Miner Res doi: 10.1002/jbmr.2609 – volume: 13 start-page: 237 issue: 3 year: 1992 ident: 2024021014284297600_jbmr3543-bib-0024 article-title: Relationships between quantitative histological measurements and noninvasive assessments of bone mass publication-title: Bone doi: 10.1016/8756-3282(92)90203-9 – volume: 29 start-page: 2504 issue: 11 year: 2014 ident: 2024021014284297600_jbmr3543-bib-0021 article-title: Postsurgical hypoparathyroidism—risk of fractures, psychiatric diseases, cancer, cataract, and infections publication-title: J Bone Miner Res doi: 10.1002/jbmr.2273 – volume: 26 start-page: 2317 issue: 10 year: 2011 ident: 2024021014284297600_jbmr3543-bib-0007 article-title: Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research publication-title: J Bone Miner Res doi: 10.1002/jbmr.483 – volume: 3 start-page: 133 issue: 2 year: 1988 ident: 2024021014284297600_jbmr3543-bib-0011 article-title: Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females publication-title: J Bone Miner Res doi: 10.1002/jbmr.5650030203 – volume: 21 start-page: 2027 issue: 12 year: 2010 ident: 2024021014284297600_jbmr3543-bib-0026 article-title: Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis publication-title: Osteoporos Int doi: 10.1007/s00198-009-1168-7 – volume: 25 start-page: 2709 issue: 12 year: 2014 ident: 2024021014284297600_jbmr3543-bib-0035 article-title: Bone quality of the newest bone formed after two years of teriparatide therapy in patients who were previously treatment-naive or on long-term alendronate therapy publication-title: Osteoporos Int doi: 10.1007/s00198-014-2814-2 – volume: 24 start-page: 1998 issue: 12 year: 2009 ident: 2024021014284297600_jbmr3543-bib-0033 article-title: Teriparatide reduces bone microdamage accumulation in postmenopausal women previously treated with alendronate publication-title: J Bone Miner Res doi: 10.1359/jbmr.090527 – volume: 23 start-page: 2018 issue: 12 year: 2008 ident: 2024021014284297600_jbmr3543-bib-0002 article-title: Dynamic and structural properties of the skeleton in hypoparathyroidism publication-title: J Bone Miner Res doi: 10.1359/jbmr.080803 – volume: 31 start-page: 180 issue: 1 year: 2016 ident: 2024021014284297600_jbmr3543-bib-0036 article-title: PTH(1-84) Administration in hypoparathyroidism transiently reduces bone matrix mineralization publication-title: J Bone Miner Res doi: 10.1002/jbmr.2588 – ident: 2024021014284297600_jbmr3543-bib-0009 – volume: 67 start-page: 246 year: 2014 ident: 2024021014284297600_jbmr3543-bib-0032 article-title: Literature review: the effects of teriparatide therapy at the hip in patients with osteoporosis publication-title: Bone doi: 10.1016/j.bone.2014.07.014 – volume: 96 start-page: 3804 issue: 12 year: 2011 ident: 2024021014284297600_jbmr3543-bib-0031 article-title: Circulating sclerostin in disorders of parathyroid gland function publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-0566 – volume: 27 start-page: 1811 issue: 8 year: 2012 ident: 2024021014284297600_jbmr3543-bib-0010 article-title: Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure publication-title: J Bone Miner Res doi: 10.1002/jbmr.1627 – volume: 97 start-page: 4507 issue: 12 year: 2012 ident: 2024021014284297600_jbmr3543-bib-0008 article-title: Long-term follow-up of patients with hypoparathyroidism publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-1808 – volume: 12 start-page: 948 issue: 6 year: 1997 ident: 2024021014284297600_jbmr3543-bib-0012 article-title: Histomorphometric assessment of bone mass, structure, and remodeling: a comparison between healthy black and white premenopausal women publication-title: J Bone Miner Res doi: 10.1359/jbmr.1997.12.6.948 – volume: 28 start-page: 2 issue: 1 year: 2013 ident: 2024021014284297600_jbmr3543-bib-0017 article-title: Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee publication-title: J Bone Miner Res doi: 10.1002/jbmr.1805 – volume: 46 start-page: 190 issue: 1 year: 2010 ident: 2024021014284297600_jbmr3543-bib-0018 article-title: Three dimensional cancellous bone structure in hypoparathyroidism publication-title: Bone doi: 10.1016/j.bone.2009.09.020 – volume: 30 start-page: 1738 issue: 9 year: 2015 ident: 2024021014284297600_jbmr3543-bib-0022 article-title: The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study publication-title: J Bone Miner Res doi: 10.1002/jbmr.2501 – volume: 28 start-page: 2277 issue: 11 year: 2013 ident: 2024021014284297600_jbmr3543-bib-0023 article-title: Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study publication-title: J Bone Miner Res doi: 10.1002/jbmr.1979 – volume: 21 start-page: 1927 issue: 11 year: 2010 ident: 2024021014284297600_jbmr3543-bib-0014 article-title: Therapy of hypoparathyroidism with intact parathyroid hormone publication-title: Osteoporos Int doi: 10.1007/s00198-009-1149-x – volume: 44 start-page: 113 issue: 1 year: 2009 ident: 2024021014284297600_jbmr3543-bib-0028 article-title: Cancellous and cortical bone architecture and turnover at the iliac crest of postmenopausal osteoporotic women treated with parathyroid hormone 1-84 publication-title: Bone doi: 10.1016/j.bone.2008.09.019 – volume: 18 start-page: 103 issue: 2 year: 1996 ident: 2024021014284297600_jbmr3543-bib-0003 article-title: Bone histomorphometry in hypoparathyroid patients treated with vitamin D publication-title: Bone doi: 10.1016/8756-3282(95)00443-2 – volume: 90 start-page: 4644 issue: 8 year: 2005 ident: 2024021014284297600_jbmr3543-bib-0034 article-title: Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trial publication-title: J Clin Endocrin Metabol doi: 10.1210/jc.2004-2489 – volume: 59 start-page: 139 year: 2014 ident: 2024021014284297600_jbmr3543-bib-0027 article-title: Effects of teriparatide on cortical histomorphometric variables in postmenopausal women with or without prior alendronate treatment publication-title: Bone doi: 10.1016/j.bone.2013.11.011 – volume: 350 start-page: 550 issue: 9077 year: 1997 ident: 2024021014284297600_jbmr3543-bib-0029 article-title: Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis publication-title: Lancet doi: 10.1016/S0140-6736(97)02342-8 – volume: 359 start-page: 391 issue: 4 year: 2008 ident: 2024021014284297600_jbmr3543-bib-0001 article-title: Clinical practice. Hypoparathyroidism publication-title: N Engl J Med doi: 10.1056/NEJMcp0803050 – volume: 24 start-page: 964 issue: 5 year: 2009 ident: 2024021014284297600_jbmr3543-bib-0037 article-title: PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation publication-title: J Bone Miner Res doi: 10.1359/jbmr.081233 – volume: 148 start-page: 535 issue: 6 year: 1989 ident: 2024021014284297600_jbmr3543-bib-0004 article-title: Biochemical markers of bone turnover, intact serum parathyroid horn and renal calcium excretion in patients with pseudohypoparathyroidism and hypoparathyroidism before and during vitamin D treatment publication-title: Eur J Pediatr doi: 10.1007/BF00441552 – volume: 82 start-page: 861 issue: 3 year: 1988 ident: 2024021014284297600_jbmr3543-bib-0005 article-title: Effects of active vitamin D3 and parathyroid hormone on the serum osteocalcin in idiopathic hypoparathyroidism and pseudohypoparathyroidism publication-title: J Clin Invest doi: 10.1172/JCI113690 – volume: 26 start-page: 2727 issue: 11 year: 2011 ident: 2024021014284297600_jbmr3543-bib-0006 article-title: PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism publication-title: J Bone Miner Res doi: 10.1002/jbmr.452 – volume: 101 start-page: 2742 issue: 7 year: 2016 ident: 2024021014284297600_jbmr3543-bib-0015 article-title: Therapy of hypoparathyroidism with PTH(1-84): a prospective six year investigation of efficacy and safety publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2015-4135 |
| SSID | ssj0006566 |
| Score | 2.4090264 |
| Snippet | ABSTRACT
Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1‐84) [rhPTH(1‐84)] in... Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] in... Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1‐84) [rhPTH(1‐84)] in... Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1–84) [rhPTH(1–84)] in... |
| SourceID | pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1931 |
| SubjectTerms | Adult Aged Bone and Bones - pathology Bone growth Bone histomorphometry Bone remodeling Bone resorption Cancellous bone Case-Control Studies Cohort Studies CORTICAL POROSITY Female HISTOMORPHOMETRY Humans HYPOPARATHYROIDISM Hypoparathyroidism - drug therapy Lamellae Long-term effects Male Middle Aged Osteogenesis Osteoid Parathyroid Parathyroid hormone Parathyroid Hormone - administration & dosage Parathyroid Hormone - pharmacology Parathyroid Hormone - therapeutic use Porosity Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use RHPTH(1‐84) Time Factors TRABECULAR TUNNELING |
| Title | The Effects of Long‐term Administration of rhPTH(1‐84) in Hypoparathyroidism by Bone Histomorphometry |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjbmr.3543 https://www.ncbi.nlm.nih.gov/pubmed/29972871 https://www.proquest.com/docview/2129534154 https://www.proquest.com/docview/2064774948 https://pubmed.ncbi.nlm.nih.gov/PMC6546298 |
| Volume | 33 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3NbtQwEMetqicuQCkfoQUZhFA5ZLtrx04iTi2iWlUUoaqVekCKbMfpBkhSZXcP4cQj8Iw8CTP2JmUpSIhDpEieKF8zmb-TmV8IeZEIaSHQdGhAXIdIAAu1FArmPGlh8lxzD54_eS-n59HxhbjYIK_7XhjPhxheuGFkuOc1BrjS8_1raOgnXbUjLiIkfWKtFgqi02t0FOoUryCx0IJPeqrQmO0PW67nohsC82ad5K_61SWgozvkY3_ovu7k82i50CPz9Teq43-e211yeyVM6YH3pC2yYet7ZPughkl51dGX1JWKunfw26QE56KeezynTUHfNfXlj2_f8SlP12m8ONrOPpxN9yZgkESvaFnTaXfVOOT4rGubMi_nFdUdPWxqSx21pGrg5jeVXbTdfXJ-9PbszTRc_bMhNFHEeShhipNA3s0tCDmuEims5TLH770TmcpcK2WlyhksZmxFomw6YQxWreCqiA1_QDZr2N8jQtlYxeNYgoLVeWSKVLE4jlPDIi6LRORJQPb6u5eZFdAc_6vxJfMoZpbhZczwMgbk-WB65SkefzLa7V0gWwXyPIPMngrI9CIKyLNhGEIQv6uo2jZLsMGG3Rg5OwF56D1m2AvDxmSYlAYkXvOlwQDx3usjdTlzmG9sM2MpnqZzlb8feHZ8eHKKK4__3XSH3ALpl_iuyl2yuWiX9gnIq4V-6uLoJ7ZTJZE |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELZKOcCFv0IJFDAIoXLIdteOnUTi0iKqUHYrVG2lXlDkJA4bIEmV3T2EE4_AM_IkzNiblKUgIQ6RLHmiJPaM5xtn5jMhzwMhNRha4qYArl1kAHMTKRTEPGGeZlnCLfH85FhGp97RmTjbIK-6WhjLD9FvuKFlmPUaDRw3pPcuWEM_JWUz4MLjV8hVPNHbBFQnF-RRiFQshsRUCz7qeIWGbK-_dd0bXYKYlzMlf0WwxgUd3iQfupe3mSefB8tFMki__sbr-L9fd4vcWGFTum-V6TbZ0NUdsrVfQVxetvQFNdmiZht-ixSgX9RSH89pndNxXX388e07LvR0nZAXe5vZ-2m0OwKBwHtJi4pG7XltWMdnbVMXWTEvadLSg7rS1BCXlDXMf13qRdPeJaeHb6avI3d1bIObeh7nroQoJwDXm2nAclwFUmjNZYa_fEcylFmilJYqY3ClQy0CpcMRY9DUgqvcT_k9slnB8-4TyobKH_oSQGySeWkeKub7fpgyj8s8EFngkN1u-uJ0xWmOR2t8iS0bM4txGGMcRoc860XPLZHHn4R2Oh2IV7Y8j8G5hwKcvfAc8rTvBivEXyuq0vUSZLBm10eqHYdsW5Xpn8KwNhniUof4a8rUCyDD93pPVcwM0zdWmrEQP9Poyt9fPD46mJxg48G_iz4h16LpZByP3x6_e0iuAxIMbJHlDtlcNEv9CNDWInlsjOon374prA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1Lb9QwEMdHpUiIC6_yCBQwCKFyyDZrx04iTi1ltZS2qqpW6gEpcmKHDZBkld09hBMfgc_IJ2Ecb1KWgoQ4RIrkifLwTObvxPMzwIuQC42BlrgpimvXEMDcRHCJY54oS5VKmAXPHx6J8Zm_f87P1-B1Vwtj-RD9BzcTGe372gT4VGXbF9DQT0lRDxj32RW46gsvNC69d3LBjjJCxUpIM9OCDTuskEe3-0NXk9ElhXl5ouSvArbNQKOb8KG7djvx5PNgMU8G6dffsI7_eXO34MZSmZId60q3YU2Xd2Bjp8RRedGQl6SdK9p-hN-AHL2LWPDxjFQZOajKjz--fTevebKK4zWt9eT4dLw1RIPQf0XykoybadUyxydNXeUqnxUkachuVWrSYkuKCnu_KvS8bu7C2ejt6Zuxu1y0wU19nzFX4BgnxMSrNCo5JkPBtWZCmR--QxEJlUiphVQUt9TTPJQ6GlKKu5ozmQUpuwfrJZ7vARDqycALBErYRPlpFkkaBEGUUp-JLOQqdGCr6704XRLNzcIaX2LLYqaxeYyxeYwOPO9Npxbj8Sejzc4F4mUkz2JM7RHHVM99B571zRiD5seKLHW1QBtTsRsY0I4D963H9GehpjIZR6UOBCu-1BsYvvdqS5lPWs63qTOjkbnN1lX-fuHx_u7hidl5-O-mT-Ha8d4oPnh39P4RXEcZGNoKy01Yn9cL_Ril1jx50obUT3MOKGQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Effects+of+Long-term+Administration+of+rhPTH%281-84%29+in+Hypoparathyroidism+by+Bone+Histomorphometry&rft.jtitle=Journal+of+bone+and+mineral+research&rft.au=Rubin%2C+Mishaela+R&rft.au=Zhou%2C+Hua&rft.au=Cusano%2C+Natalie+E&rft.au=Majeed%2C+Rukshana&rft.date=2018-11-01&rft.issn=0884-0431&rft.eissn=1523-4681&rft.volume=33&rft.issue=11&rft.spage=1931&rft.epage=1939&rft_id=info:doi/10.1002%2Fjbmr.3543&rft_id=info%3Apmid%2F29972871&rft.externalDocID=PMC6546298 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0884-0431&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0884-0431&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0884-0431&client=summon |