KSHV viral load and Interleukin‐6 in HIV‐associated pediatric Kaposi sarcoma—Exploring the role of lytic activation in driving the unique clinical features seen in endemic regions

• Published in: International journal of cancer Vol. 144; no. 1; pp. 110 - 116
• Main Authors: El‐Mallawany, Nader Kim, Mehta, Parth S., Kamiyango, William, Villiera, Jimmy, Peckham‐Gregory, Erin C., Kampani, Coxcilly, Krysiak, Robert, Sanders, Marcia K., Caro‐Vegas, Carolina, Eason, Anthony B., Ahmed, Saeed, Schutze, Gordon E., Martin, Stephen C., Kazembe, Peter N., Scheurer, Michael E., Dittmer, Dirk P.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2019
• Subjects: Activation; Adolescent; Cancer; Child; Child, Preschool; Children; Cytokines; Edema; Endemic Diseases; Female; global health; Herpesviridae Infections - epidemiology; Herpesviridae Infections - metabolism; Herpesviridae Infections - virology; Herpesvirus 8, Human - physiology; HHV8; HIV; HIV Infections - epidemiology; HIV Infections - metabolism; HIV Infections - virology; human herpesvirus8; Human immunodeficiency virus; Humans; IL‐6; Infant; Interleukin-6 - metabolism; interleukin‐6; Kaposi sarcoma; Kaposi sarcoma‐associated herpesvirus; Kaposis sarcoma; KSHV; Lesions; Lymphadenopathy; Malawi - epidemiology; Male; Medical research; Mucosa; pediatric oncology; Pediatrics; Pilot Projects; Prospective Studies; Sarcoma; Sarcoma, Kaposi - epidemiology; Sarcoma, Kaposi - metabolism; Sarcoma, Kaposi - virology; Skin diseases; Viral Load; Virus Activation - physiology; Viruses; Malawi; Africa; global health; Kaposi sarcoma; Kaposi sarcoma-associated herpesvirus; HHV8; HIV; pediatric oncology; KSHV; IL-6; human herpesvirus8; interleukin-6

Kaposi sarcoma (KS) is among the most common childhood malignancies in central, eastern, and southern Africa. Although its unique clinical features have been established, biological mechanisms related to the causative agent, KS‐associated herpes‐virus (KSHV), have yet to be explored in children. We...