Automated T2 relaxometry of the hippocampus for temporal lobe epilepsy

• Published in: Epilepsia (Copenhagen) Vol. 58; no. 9; pp. 1645 - 1652
• Main Authors: Winston, Gavin P., Vos, Sjoerd B., Burdett, Jane L., Cardoso, M. Jorge, Ourselin, Sebastien, Duncan, John S.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2017; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Aged; Automation; Automation - methods; Case-Control Studies; Cerebrospinal fluid; Contamination; Epilepsy; Epilepsy, Temporal Lobe - diagnostic imaging; Epilepsy, Temporal Lobe - etiology; Epilepsy, Temporal Lobe - pathology; Epilepsy, Temporal Lobe - physiopathology; Female; Full‐Length Original Research; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - pathology; Hippocampus - physiopathology; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Middle Aged; Sclerosis; Segmentation; T2 relaxometry; Temporal lobe; Temporal lobe epilepsy; Young Adult; Temporal lobe epilepsy; T2 relaxometry; Magnetic resonance imaging; Hippocampus

Summary Objective Hippocampal sclerosis (HS), the most common cause of refractory temporal lobe epilepsy, is associated with hippocampal volume loss and increased T2 signal. These can be identified on quantitative imaging with hippocampal volumetry and T2 relaxometry. Although hippocampal segmentati...