Sex differences in oral oxycodone self‐administration and stress‐primed reinstatement in rats

• Published in: Addiction biology Vol. 25; no. 6; pp. e12822 - n/a
• Main Authors: Fulenwider, Hannah D., Nennig, Sadie E., Hafeez, Hiba, Price, Michaela E., Baruffaldi, Federico, Pravetoni, Marco, Cheng, Kejun, Rice, Kenner C., Manvich, Daniel F., Schank, Jesse R.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2020
• Subjects: Analgesics, Opioid - administration & dosage; Analgesics, Opioid - blood; Animals; Cocaine; Drug-Seeking Behavior - drug effects; Estrous Cycle - drug effects; Extinction, Psychological - drug effects; Female; Females; Gender differences; Male; Naloxone - administration & dosage; Narcotics; Neurokinin; Neurokinin-1 Receptor Antagonists - pharmacology; Operant conditioning; opiate; Opioid receptors (type mu); Oral administration; Oxycodone; Oxycodone - administration & dosage; Oxycodone - blood; Prescription Drug Misuse; Public health; Rats; Rats, Wistar; Receptors, Neurokinin-1 - physiology; Receptors, Opioid, mu - antagonists & inhibitors; Reinstatement; Self Administration; Sex differences; reinstatement; self-administration; opiate

The opioid epidemic has become a severe public health problem, with approximately 130 opioid‐induced deaths occurring each day in the United States. Prescription opioids are responsible for approximately 40% of these deaths. Oxycodone is one of the most commonly abused prescription opioids, but desp...